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In patients receiving capecitabine monotherapy, rs4702484, located in ADCY2 and close to MTRR (show MTRR ELISA Kits), was associated with slightly reduced PFS for homozygous wild-type patients (CC 6.2 vs. CT 8.0 months; P=0.018).
Our present study defines an AC2 cAMP signaling compartment that specifically regulates IL-6 (show IL6 ELISA Kits) expression in bronchial smooth muscle cells.
AKAP79 (show AKAP5 ELISA Kits), PKC, PKA and PDE4 (show PDE4A ELISA Kits) participate in a Gq-linked muscarinic receptor (show CHRM5 ELISA Kits) and adenylate cyclase 2 cAMP signalling complex.
AGS3 reduced D(2L)DR-mediated sensitization of AC1 and AC2.
A replication of association between two SNPs previously associated with COPD (show ARCN1 ELISA Kits) (CHRNA3 (show CHRNA3 ELISA Kits)/5 and IREB2 (show IREB2 ELISA Kits)), as well as an association with COPD (show ARCN1 ELISA Kits) of one locus initially associated with lung function (ADCY2).
Data suggest that SPARCL1, Shp2 (show PTPN11 ELISA Kits), MSH2 (show MSH2 ELISA Kits), E-cadherin (show CDH1 ELISA Kits), p53 (show TP53 ELISA Kits), ADCY-2 and MAPK (show MAPK1 ELISA Kits) are potential prognostic markers in colorectal cancer.
AC2 and AC4 (show ADCY4 ELISA Kits) isoforms, stimulated by GTP binding protein betagamma subunits, are expressed in bronchial nonlipid raft membrane fractions where they colocalize with and couple to prostanoid EP2 receptors.
AC2 interacts with RXFP1 (show RXFP1 ELISA Kits) through AKAP79 (show AKAP5 ELISA Kits), whereas the association with PDE4D3 and PKA depends upon beta-arrestin 2 (show ARRB2 ELISA Kits) binding to Ser704.
This study demonistrated that adcy2 knockout mice regulate the expression soluble adenylyl cyclase (show ADCY10 ELISA Kits) in brain.
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.
3',5'-cyclic AMP synthetase
, ATP pyrophosphate-lyase 2
, adenylate cyclase II
, adenylate cyclase type 2
, adenylate cyclase type II
, adenylyl cyclase 2
, type II adenylate cyclase