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Browse our Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) ELISA Kits

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Adrenergic, Beta, Receptor Kinase 1 ELISA Kits (ADRBK1)
On www.antibodies-online.com are 16 Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) ELISA Kits from 8 different suppliers available. Additionally we are shipping Adrenergic, Beta, Receptor Kinase 1 Antibodies (111) and Adrenergic, Beta, Receptor Kinase 1 Proteins (6) and many more products for this protein. A total of 149 Adrenergic, Beta, Receptor Kinase 1 products are currently listed.
Synonyms:
Adrbk-1, Bark-1, BARK1, BETA-ARK1, betaARK1, GRK-2, Grk2
list all ELISA KIts Gene Name GeneID UniProt
ADRBK1 110355  
ADRBK1 156 P25098
ADRBK1 25238 P26817

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Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) ELISA Kits by Reactivity

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More ELISA Kits for Adrenergic, Beta, Receptor Kinase 1 Interaction Partners

Mouse (Murine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. In vitro, GRK2 inhibits Epac1 (show RAPGEF3 ELISA Kits)-to-Rap1 (show TERF2IP ELISA Kits) signaling by phosphorylation of Epac1 (show RAPGEF3 ELISA Kits) at Ser (show SIGLEC1 ELISA Kits)-108 in the Disheveled/Egl-10/pleckstrin (show PLEK ELISA Kits) domain. GRK2 inhibits Epac1 (show RAPGEF3 ELISA Kits)-mediated sensitization of Piezo2 (show FAM38B ELISA Kits) which contributes to inflammatory mechanical hyperalgesia.

  2. GRK2 ablation increases circadian amplitude and decreases circadian period. GRK2 suppresses mPeriod1 transcription,PERIOD1/2 nuclear trafficking and promotes PERIOD2 phosphorylation.

  3. These results suggest GRK2 contributes to melanopsin (show OPN4 ELISA Kits) deactivation, but that other mechanisms account for most of modulation of melanopsin (show OPN4 ELISA Kits) activity in ipRGCs.

  4. data suggest that inhibiting GRK2 could reverse an established insulin (show INS ELISA Kits)-resistant and obese phenotype

  5. Post-MI AdipoR1 (show ADIPOR1 ELISA Kits) phosphorylation positively correlated with the expression level of GRK2. AdipoR1 (show ADIPOR1 ELISA Kits) is phosphorylatively modified and desensitized by GRK2 in failing cardiomyocytes, contributing to post-MI remodeling and HF progression.

  6. findings indicate that the balance between mechanisms regulating vascular tone are shifted to favor vasoconstriction in the absence of GRK2 expression and that this leads to the age-dependent development of hypertension

  7. Data indicate that G protein-coupled receptor kinase 2 (GRK2) downregulation enhances insulin (show INS ELISA Kits) signaling in adult mouse hearts.

  8. Findings reveal a cell-type-specific role for GRK2 in the regulation of normal motor behavior, sensitivity to psychostimulants, dopamine neurotransmission, and D2 autoreceptor function

  9. Attenuation of GRK2 is associated with defective differentiation of somatic muscles.

  10. These data demonstrate that GRK2 modulates FcinRI signaling in mast cells via at least two mechanisms.One involves GRK2-RH and modulates tyrosine phosphorylation of Syk (show SYK ELISA Kits), and the other is mediated via the phosphorylation of p38 (show CRK ELISA Kits) and Akt (show AKT1 ELISA Kits).

Cow (Bovine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. Mitochondrial-targeted GRK2 is essential for prodeath signaling occurring after oxidative stress in myocytes and assigning a novel role for this GRK (show GRK4 ELISA Kits).

  2. Indicate that the anti-proliferative function of elevated GRK2 in hepatocellular carcinoma is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent.

  3. G alpha q/11 interacts with this protein. A novel surface on a regulator of G protein signals a homology domain for binding G alpha subunits (GRK2 kinase}

  4. determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits.

  5. intramolecular interactions could play a role in regulating G protein-coupled receptor kinase 2 (GRK2).

  6. epithelial Na-channels are maintained in the active state by Grk2; Grk2 phosphorylates the C terminus of the channel beta subunit and renders the channels insensitive to inhibition by Nedd4-2.

  7. Crystallographic and biochemical studies provide evidence that the major domain interfaces of G protein-coupled beta adrenergic receptor kinase 1 (GRK2) remain associated during Gbetagamma binding and activation of GRK2.

  8. Resultrs suggest that activated platelet-derived growth factor receptor-beta (show PDGFRB ELISA Kits) (PDGFRbeta) phosphorylates GRK2 tyrosyl residues and thereby activates GRK2, which then serine-phosphorylates and desensitizes the PDGFRbeta.

  9. GRK2-as5 has a role in membrane trafficking of the mu-opioid receptor (show OPRM1 ELISA Kits)

  10. atomic structure of GRK2 in complex with Galphaq (show GNAQ ELISA Kits) and Gbetagamma, in which activated Galpha (show SUCLG1 ELISA Kits) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [Galphaq (show GNAQ ELISA Kits), Gbetagamma

Human Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. the dual-specific GRK2 and ERK (show EPHB2 ELISA Kits) cascade inhibitor, RKIP (Raf kinase inhibitor protein (show PEBP1 ELISA Kits)), triggered dysfunctional cardiomyocyte energetics and the expression of heart failure-promoting Pparg (show PPARG ELISA Kits)-regulated genes.

  2. Acute mental stress significantly increased GRK2 density in in peripheral blood mononuclear cells of young adult males.

  3. It plays a role in progression of Vasculature which is affected by insulin (show INS ELISA Kits) resistance and type 2 diabetes expresses high levels of GRK2

  4. Data suggest that, by targeting/repressing GRK2, microRNA-K3 of Kaposi sarcoma-associated herpesvirus (KSHV) facilitates migration and invasion of vascular endothelial cells via activation of CXCR2 (show CXCR2 ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling.

  5. Acute aerobic exercise induces a greater GRK2 expression in women than men, while increased cardiorespiratory fitness is associated with exercise-induced GRK2 expression in PBMCs

  6. Data indicate that protein kinase (show CDK7 ELISA Kits) GRK2 silencing abolished isoproterenol-induced phosphorylation of beta2-adrenergic receptor (show ADRB2 ELISA Kits) (beta2ARs).

  7. G protein beta subunits (Gb) bind to DDB1 and Gb2 targets GRK2 for ubiquitylation by the DDB1-CUL4A-ROC1 ubiquitin ligase.

  8. A thorough understanding of the functions of GRK2 in the heart is necessary in order to finalize it as a candidate for drug development.

  9. Knockdown of ADRBK1 gene has detrimental effects on breast cancer cell growth.

  10. Results uncovered that Gaq (show GNAQ ELISA Kits) binding to GRK2 enhances the recruitment of GRK2 to M3-ACh (show FGFR3 ELISA Kits) receptors.

Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Antigen Profile

Antigen Summary

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Alternative names and synonyms associated with Adrenergic, Beta, Receptor Kinase 1 (ADRBK1)

  • beta-adrenergic receptor kinase 1 (Tsp_00497) Elisa Kit
  • adrenergic, beta, receptor kinase 1 (adrbk1) Elisa Kit
  • adrenergic receptor kinase, beta 1 (Adrbk1) Elisa Kit
  • adrenergic, beta, receptor kinase 1 (ADRBK1) Elisa Kit
  • adrenergic, beta, receptor kinase 1 (Adrbk1) Elisa Kit
  • Adrbk-1 Elisa Kit
  • Bark-1 Elisa Kit
  • BARK1 Elisa Kit
  • BETA-ARK1 Elisa Kit
  • betaARK1 Elisa Kit
  • GRK-2 Elisa Kit
  • Grk2 Elisa Kit

Protein level used designations for ADRBK1

beta-adrenergic receptor kinase 1 , adrenergic, beta, receptor kinase 1 , G-protein-coupled receptor kinase 2 , beta ARK , beta ARK1 , beta-AR kinase-1 , beta-ARK-1 , beta-adrenergic receptor kinase-1 , G-protein coupled receptor kinase 2 , adrenergic receptor kinase, beta 1 , beta-adrenergic receptor kinase 1 beta ARK1

GENE ID SPECIES
10901826 Trichinella spiralis
100555775 Anolis carolinensis
110355 Mus musculus
282682 Bos taurus
156 Homo sapiens
25238 Rattus norvegicus
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