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anti-Human AFAP1L2 Antibodies:
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Human Polyclonal AFAP1L2 Primary Antibody for EIA, IHC (p) - ABIN499229
Lodyga, De Falco, Bai, Kapus, Melillo, Santoro, Liu: XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway. in Oncogene 2009
Show all 2 references for ABIN499229
XB130 is a mediator for nicotine-derived nitrosamine ketone-induced cell migration through its translocation to cell motility related microfilamentous cellular structures.
XB130 could be useful as a prognostic marker of recurrence-free and overall survival in invasive ductal breast cancer, as well as for the response to chemotherapy.
This is the first study to reveal that XB130 overexpression may be related to the prediction of metastasis potency and poor prognosis for osteosarcoma patients
Results showed significant interaction between variants at TERF1 (show TERF1 Antibodies) and AFAP1L2 loci. Given the key role of TERF1 (show TERF1 Antibodies) in telomere biology and its physical interaction with AFAP1L2, these results support a role for telomere dysfunction in melanoma development.
High XB130 expression is associated with pancreatic ductal adenocarcinoma.
XB130 enhances cell motility and invasiveness by modulating the epithelial-mesenchymal transition-like process.
High nuclear expression of XB130 is associated with esophageal squamous cell carcinoma.
XB130 could promote growth of cancer cells by regulating expression of tumor suppressive miRNAs and their targeted genes.
XB130 is a substrate of multiple protein tyrosine kinases, and it can regulate cell proliferation and survival through modulating selected down-stream signals of PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway
reduced XB130 protein expression is a prognostic biomarker for shorter survival and a higher recurrence rate in patients with gastric cancer
May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation (By similarity).
AFAP1-like protein 2
, actin filament-associated protein 1-like 2
, phosphatidylinositol 3-kinase-associated protein