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this study determined a structure of AP2 that includes the clathrin-binding beta2 hinge.
Results suggest that autosomal recessive hypercholesterolemia (ARH) and beta-arrestin depend on a privileged AP2beta2 appendage site for proper cargo recruitment to clathrin bud sites.
multiple interactions between PIPKI gamma-p90 and AP-2 lead to spatiotemporally controlled PI(4,5)P(2) synthesis during clathrin-mediated synaptic vesicle endocytosis
interactions of the EGF receptor (show EGFR Proteins) with AP-2 (show GTF3A Proteins) mediated by the receptor 974YRAL and di-leucine motifs may contribute to beta2 tyrosine phosphorylation
the AP-2 complex is not associated with the endocytosed plasma membrane-associated clathrin
AP2 (show GTF3A Proteins) regulates thrombin receptor (show F2R Proteins) constitutive internalization and endothelial cell resensitization.
Clathrin, which interacts with the AP2beta-appendage, achieves ligand displacement in vivo by self-polymerisation as the coated pit (show IRF6 Proteins) matures.
EGFR (show EGFR Proteins), fibrillin-2 (show FBN2 Proteins), P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics.
The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene.
AP-2 complex subunit beta
, AP-2 complex subunit beta-1
, adaptor-related protein complex 2, beta 1 subunit
, adapter-related protein complex 2 beta subunit
, adaptin, beta 2 (beta)
, adaptor protein complex AP-2 subunit beta
, clathrin assembly protein complex 2 beta large chain
, clathrin-associated/assembly/adaptor protein, large, beta 1
, plasma membrane adaptor HA2/AP2 adaptin beta subunit
, AP-1 complex subunit beta-1
, adapter-related protein complex 1 subunit beta-1
, adaptor protein complex AP-1 subunit beta-1
, beta-adaptin 1
, clathrin assembly protein complex 1 beta large chain
, clathrin-associated / assembly / adaptor protein, large, beta 1
, golgi adaptor HA1/AP1 adaptin beta subunit
, beta adaptin