Browse our AP2S1 (AP2S1) ELISA Kits

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Adaptor-Related Protein Complex 2, sigma 1 Subunit ELISA Kits (AP2S1)
On are 2 Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1) ELISA Kits from 2 different suppliers available. Additionally we are shipping AP2S1 Antibodies (37) and AP2S1 Proteins (13) and many more products for this protein. A total of 55 AP2S1 products are currently listed.
AI043088, AP2S1, Ap17, AP17-DELTA, CLAPS2, DDBDRAFT_0188542, DDBDRAFT_0234236, DDB_0188542, DDB_0234236, HHC3, MGC85224
list all ELISA KIts Gene Name GeneID UniProt
AP2S1 1175 P53680
Mouse AP2S1 AP2S1 232910 P62743
Rat AP2S1 AP2S1 65046 P62744

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More ELISA Kits for AP2S1 Interaction Partners

Human Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1) interaction partners

  1. CaSR (show CASR ELISA Kits) and AP2S1 sequencing is worthwhile in patients with familial hyperparathyroidism and phenotype suggesting familial hypocalciuric hypercalcemia as it can diagnose up to 50% of cases.

  2. In 33 CASR (show CASR ELISA Kits)-negative patients with suspected FHH (show CASR ELISA Kits), Data found two (~6%) with a mutation in AP2S1 (p.Arg15Leu and p.Arg15His). Family screening confirmed the genotype-phenotype correlations. Data did not identify any pathogenic mutations in GNA11 (show GNA11 ELISA Kits).

  3. our studies demonstrate AP2sigma2 mutations to result in a more severe FHH (show CASR ELISA Kits) phenotype with genotype-phenotype correlations, and a dominant-negative mechanism of action with mutational bias at the Arg15 residue.

  4. The results affirm that a significant number of patients suspected of having Familial hypocalciuric hypercalcemia but proven negative for CASR (show CASR ELISA Kits) mutation have AP2S1 p.R15 mutations.

  5. The absence of AP2S1 abnormalities in hypocalcemic patients, suggests that autosomal dominant hypocalcemia 3 (ADH3) may not occur or otherwise represents a rare hypocalcemic disorder.

  6. None of the 60 patients presented with nucleotidic changes or copy number variation in the AP2S1 gene, thereby excluding AP2S1 defects as a frequent cause of isolated hypoparathyroidism.

  7. Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3.

AP2S1 Antigen Profile

Antigen Summary

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.

Alternative names and synonyms associated with AP2S1

  • adaptor-related protein complex 2, sigma 1 subunit (AP2S1) Elisa Kit
  • adaptor-related protein complex 2, sigma 1 subunit (ap2s1) Elisa Kit
  • adaptor-related protein complex 2, sigma 1 subunit (Ap2s1) Elisa Kit
  • AI043088 Elisa Kit
  • AP2S1 Elisa Kit
  • Ap17 Elisa Kit
  • AP17-DELTA Elisa Kit
  • CLAPS2 Elisa Kit
  • DDBDRAFT_0188542 Elisa Kit
  • DDBDRAFT_0234236 Elisa Kit
  • DDB_0188542 Elisa Kit
  • DDB_0234236 Elisa Kit
  • HHC3 Elisa Kit
  • MGC85224 Elisa Kit

Protein level used designations for AP2S1

adaptor-related protein complex 2, sigma 1 subunit , AP-2 complex subunit sigma , AP-2 complex subunit sigma isoform AP17 , sigma adaptin , HA2 17 kDa subunit , adaptor protein complex AP-2 subunit sigma , clathrin assembly protein 2 small chain , clathrin coat assembly protein AP17 , clathrin coat-associated protein AP17 , clathrin-associated/assembly/adaptor protein, small 2 (17kD) , plasma membrane adaptor AP-2 17 kDa protein , sigma2-adaptin , adapter-related protein complex 2 sigma subunit , sigma-adaptin 3b , clathrin-associated protein 17 , AP-2 complex subunit sigma-1

431511 Gallus gallus
456156 Pan troglodytes
549079 Xenopus (Silurana) tropicalis
716911 Macaca mulatta
8627289 Dictyostelium discoideum AX4
447078 Xenopus laevis
476427 Canis lupus familiaris
1175 Homo sapiens
232910 Mus musculus
65046 Rattus norvegicus
536553 Bos taurus
100172940 Pongo abelii
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