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Human ARF4 Protein expressed in Wheat germ - ABIN1345461
Norton, Lawson, Mahdi, Freytag, Clements: The A subunit of Escherichia coli heat-labile enterotoxin functions as a mucosal adjuvant and promotes IgG2a, IgA, and Th17 responses to vaccine antigens. in Infection and immunity 2012
The newly identified ciliary targeting VxPx motif present in rhodopsin (show RHO Proteins) binds the small GTPase (show RACGAP1 Proteins) Arf4 and regulates its association with the trans-Golgi network.
Data suggest that, when compared to intestinal epithelial cells (IECs) from germ-free mice, IECs from mice with commensal bacteria exhibit increased expression of microRNA-21-5p; up-regulation of expression of microRNA-21-5p appears to increase IEC permeability and up-regulates ADP ribosylation factor 4 (Arf4/ARF4) in mouse and human cells.
ARF4 is required for Presenilin basal body localization, Notch (show NOTCH1 Proteins) signaling, and subsequent epidermal differentiation.
These findings are consistent with Arf4 playing a critical role in endomembrane trafficking, particularly in the pancreas, but not in ciliary function.
This work suggests that while Arf4 is not required for ciliary assembly, it is important for the efficient transport of fibrocystin to cilia, and also plays critical roles in non-ciliary processes
Findings suggest that Arf4 is a critical modulator of DG-mediated pattern separation by regulating dendritic spine development.
ASAP1 is a scaffold bringing together the proteins needed for transport to the cilia including the GTP-binding protein Arf4 & the 2 G proteins of the Rab family--Rab11 & Rab8--linked by the Rab8 guanine nucleotide exchange factor Rabin8.
somal CAPS2 (show CADPS2 Proteins) is associated with the Golgi membrane, and mediates binding and recruitment of the GDP-bound form of ARF4 and ARF5 (show ARF5 Proteins) to the Golgi membrane
a functional role for CAPS1 (show CAPS Proteins) in regulating DCV trafficking in the trans-Golgi network; this activity occurs via protein-protein interaction with ARF4/ARF5 (show ARF5 Proteins) in a GDP-dependent manner.
ARF1 (show ARF1 Proteins)+ARF4 are required for integrity of recycling endosomes but are involved in distinct transport pathways: the pair regulates retrograde transport from endosomes to the TGN (show TG Proteins).
A CREB3 (show CREB3 Proteins)-ARF4 signalling cascade may be part of a Golgi stress response set in motion by stimuli compromising Golgi capacity.
a crucial role for class II Arf proteins (Arf4 and Arf5 (show ARF5 Proteins)) in the dengue flavivirus life cycle
The lipid droplets deposition and the cellular triacylglycerol content are significantly increased by siRNA-mediated depletion of Arf4.
sLZIP-regulated ARF4 expression in response to phorbol 12-myristate 13-acetate is involved in breast cancer cell migration.
Arf4 regulates PLA2G6 (show PLA2G6 Proteins)-A activity together with Arf1 (show ARF1 Proteins); and gene silencing of Arf4 was shown to alter cytosolic coat protein (show GOLPH3 Proteins) I (show ANXA2 Proteins) subunit recruitment to the early secretory pathway.
ARF4 is a critical molecule that directly regulates cellular phospholipase D2 (show PLD2 Proteins) activity and this ARF4-mediated PLD2 (show PLD2 Proteins) activation stimulates AP-1 (show FOSB Proteins)-dependent transcription in the EGF (show EGF Proteins)-induced cellular response
ARF4L (show ARL4D Proteins) occurred on the plasma membrane after binding to GTP (show AK3 Proteins) and into endosomes while binding to GDP; the inactive form of ARF4L (show ARL4D Proteins) causes localization of transferrin (show Tf Proteins) receptors to the endosomes while the active form causes transport to the plasma membrane.
ARF4 participates in the regulation of glioblastoma apoptosis through the inhibition of stress-mediated apoptotic signals
swine ARF4 gene is over expressed in muscle, fat, heart, spleen, liver, and ovary and moderately expressed in lung and kidney but weakly expressed in small intestine
This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III\; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene.
ADP-ribosylation factor 4
, ADP-ribosylation factor 2
, ADP-ribosylation factor family-like protein