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Chicken Monoclonal BCAR1 Primary Antibody for IHC (f), IF - ABIN967871
Derkinderen, Toutant, Kadaré, Ledent, Parmentier, Girault: Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus. in The Journal of biological chemistry 2001
Show all 5 references for ABIN967871
Human Monoclonal BCAR1 Primary Antibody for WB - ABIN967617
Goldberg, Alexander, Pellicena, Zhang, Tsuda, Miller: Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. in The Journal of biological chemistry 2003
Show all 2 references for ABIN967617
bcar3 gene is expressed downstream of Gata2 (show GATA2 Antibodies) during gastrulation, and is co-expressed with gata2 (show GATA2 Antibodies) but is more broadly expressed during later development; its binding partner, bcar1 shows overlapping expression patterns
Tyrosine phosphorylation of focal adhesion kinase (FAK) and p130 (show RBL2 Antibodies) Crk-associated substrate (CAS) was found to be correlated with pancreatic cancer cell invasiveness.
Full-length and truncated p130Cas phosphorylated substrate domain molecules were expressed in breast cancer cells. Breast cancer cells expressing the full-length SD and the functional smaller SD fragment (spanning SD motifs 6-10) were injected into the mammary fat pads of mice. Both the complete and truncated SD significantly increased the occurrence of metastases to multiple organs.
Elevated levels of p130Cas is associated with trastuzumab resistance in breast cancer.
blockade of GD3-mediated growth signaling pathways by siRNAs might be a novel and promising therapeutic strategy against malignant melanomas, provided signaling molecules such as p130Cas and paxillin (show PXN Antibodies) are significantly expressed in individual cases.
expression quantitative trait loci studies implicate BCAR1 as the causal gene of coronary artery disease Carotid intima-media thickness
p130(Cas) exon 1 variants display altered functional properties; shorter 1B isoform exhibited diminished FAK (show PTK2 Antibodies) binding activity + reduced cell migration + invasion; longest variant 1B1 exhibited the most efficient FAK (show PTK2 Antibodies) binding + greatly enhanced migration
these data identify a new p130Cas/Cyclooxygenase-2 (show PTGS2 Antibodies) axis as a crucial element in the control of breast tumor plasticity.
Data introduce hitherto unappreciated paradigms whereby reactive oxygen species can reciprocally regulate the cellular localization of pro- and anti-migratory signaling molecules, p130cas and PTEN (show PTEN Antibodies), respectively.
BCAR1 has a pivotal role in the regulation of tissue homeostasis in pathological conditions such as cancer. (Review)
Cas promotes cell migration by linking actomyosin contractions to the adhesion complexes through interaction with Src and the actin cytoskeleton.
reduction of p130Cas levels by siRNA affects process outgrowth, the thickness of cellular processes and migration behavior of Oli (show TOMM22 Antibodies)-neu cells. long term p130Cas reduction results in increased apoptosis in cultured primary oligodendrocytes.
CRP2 (show CEBPB Antibodies) sequesters p130Cas at focal adhesions, thereby reducing lamellipodia formation and blunting vascular smooth muscle cell migration.
p130Cas plays pivotal roles in osteoclastic bone resorption.
31-kDa caspase (show CASP3 Antibodies)-generated cleavage product of p130Cas inhibited MyoD (show MYOD1 Antibodies)-induced transcriptional activation of muscle-specific (show EIF3K Antibodies) genes.
beta1-Integrin signaling within migrating ganglion cell layer cells requires Cas (show CTNND1 Antibodies) signaling-adaptor proteins
Crk-associated substrate -vinculin (show VCL Antibodies) binding significantly affects the dynamics of Crk-associated substrate and vinculin (show VCL Antibodies) within focal adhesions as well as the size of focal adhesions.
we provide evidence that exercise-induced p38 MAPK (show MAPK14 Antibodies) signaling is not impaired by the muscle-specific (show EIF3K Antibodies) deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skeletal muscle adaptation.
study described a molecular complex of PTPalpha (show PTPRA Antibodies)-BCAR3 (show BCAR3 Antibodies)-Cas (show CTNND1 Antibodies)-Src (show SRC Antibodies); this complex forms in response to PTPalpha (show PTPRA Antibodies) Tyr789 phosphorylation and mediates Cas (show CTNND1 Antibodies) localization to focal adhesions and Cas (show CTNND1 Antibodies) downstream signaling to promote cell migration
p130Cas phosphorylation, mediated by integrin beta3, facilitates cofilin inactivation and promotes myogenic differentiation through modulating actin cytoskeleton remodelling
Cas (show CTNND1 Antibodies) is required for apoptosis that is induced by proteasome inhibition, and potentially by other death stimuli.
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006
breast cancer anti-estrogen resistance 1
, breast cancer anti-estrogen resistance protein 1-like
, Cas scaffolding protein family member 1
, Crk-associated substrate p130Cas
, breast cancer anti-estrogen resistance protein 1
, CRK-associated substrate
, p130 Cas
, v-crk-associated tyrosine kinase substrate