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Browse our anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) Antibodies

Full name:
anti-Breast Cancer Anti-Estrogen Resistance 1 Antibodies (BCAR1)
On www.antibodies-online.com are 166 Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) Antibodies from 20 different suppliers available. Additionally we are shipping Breast Cancer Anti-Estrogen Resistance 1 Kits (18) and Breast Cancer Anti-Estrogen Resistance 1 Proteins (6) and many more products for this protein. A total of 199 Breast Cancer Anti-Estrogen Resistance 1 products are currently listed.
Synonyms:
AI385681, BCAR1, Cas, CAS1, CASS1, CRKAS, fc17f11, MGC68466, P130CAS, wu:fc17f11, zgc:175192
list all antibodies Gene Name GeneID UniProt
BCAR1 9564 P56945
BCAR1 12927 Q61140
BCAR1 25414 Q63767

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Most Popular Reactivities for anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) Antibodies

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Top referenced anti-Breast Cancer Anti-Estrogen Resistance 1 Antibodies

  1. Chicken Monoclonal BCAR1 Primary Antibody for IHC (f), IF - ABIN967871 : Derkinderen, Toutant, Kadaré, Ledent, Parmentier, Girault: Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for ABIN967871

  2. Human Monoclonal BCAR1 Primary Antibody for WB - ABIN967617 : Goldberg, Alexander, Pellicena, Zhang, Tsuda, Miller: Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for ABIN967617

More Antibodies against Breast Cancer Anti-Estrogen Resistance 1 Interaction Partners

Xenopus laevis Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) interaction partners

  1. bcar3 gene is expressed downstream of Gata2 (show GATA2 Antibodies) during gastrulation, and is co-expressed with gata2 (show GATA2 Antibodies) but is more broadly expressed during later development; its binding partner, bcar1 shows overlapping expression patterns

Human Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) interaction partners

  1. blockade of GD3-mediated growth signaling pathways by siRNAs might be a novel and promising therapeutic strategy against malignant melanomas, provided signaling molecules such as p130Cas and paxillin (show PXN Antibodies) are significantly expressed in individual cases.

  2. expression quantitative trait loci studies implicate BCAR1 as the causal gene of coronary artery disease Carotid intima-media thickness

  3. p130(Cas) exon 1 variants display altered functional properties; shorter 1B isoform exhibited diminished FAK (show PTK2 Antibodies) binding activity + reduced cell migration + invasion; longest variant 1B1 exhibited the most efficient FAK (show PTK2 Antibodies) binding + greatly enhanced migration

  4. these data identify a new p130Cas/Cyclooxygenase-2 (show PTGS2 Antibodies) axis as a crucial element in the control of breast tumor plasticity.

  5. Data introduce hitherto unappreciated paradigms whereby reactive oxygen species can reciprocally regulate the cellular localization of pro- and anti-migratory signaling molecules, p130cas and PTEN (show PTEN Antibodies), respectively.

  6. BCAR1 has a pivotal role in the regulation of tissue homeostasis in pathological conditions such as cancer. (Review)

  7. Cas promotes cell migration by linking actomyosin contractions to the adhesion complexes through interaction with Src and the actin cytoskeleton.

  8. Collectively, these studies demonstrate that p130Cas acts as a bridging molecule between the Kaposi's sarcoma-associated herpesvirus-induced entry signal complex and the downstream trafficking signalosome in endothelial cells.

  9. Our results show that endogenous Cul5 (show CUL5 Antibodies) suppresses epithelial cell transformation by several pathways, including inhibition of Src (show SRC Antibodies)-Cas (show CSE1L Antibodies)-induced ruffling through SOCS6 (show SOCS6 Antibodies)

  10. Increased BCAR1 expression is associated with non-small cell lung cancer.

Mouse (Murine) Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) interaction partners

  1. reduction of p130Cas levels by siRNA affects process outgrowth, the thickness of cellular processes and migration behavior of Oli (show TOMM22 Antibodies)-neu cells. long term p130Cas reduction results in increased apoptosis in cultured primary oligodendrocytes.

  2. CRP2 (show CEBPB Antibodies) sequesters p130Cas at focal adhesions, thereby reducing lamellipodia formation and blunting vascular smooth muscle cell migration.

  3. p130Cas plays pivotal roles in osteoclastic bone resorption.

  4. 31-kDa caspase (show CASP3 Antibodies)-generated cleavage product of p130Cas inhibited MyoD (show MYOD1 Antibodies)-induced transcriptional activation of muscle-specific (show EIF3K Antibodies) genes.

  5. beta1-Integrin signaling within migrating ganglion cell layer cells requires Cas (show CTNND1 Antibodies) signaling-adaptor proteins

  6. Crk-associated substrate -vinculin (show VCL Antibodies) binding significantly affects the dynamics of Crk-associated substrate and vinculin (show VCL Antibodies) within focal adhesions as well as the size of focal adhesions.

  7. we provide evidence that exercise-induced p38 MAPK (show MAPK14 Antibodies) signaling is not impaired by the muscle-specific (show EIF3K Antibodies) deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skeletal muscle adaptation.

  8. study described a molecular complex of PTPalpha (show PTPRA Antibodies)-BCAR3 (show BCAR3 Antibodies)-Cas (show CTNND1 Antibodies)-Src (show SRC Antibodies); this complex forms in response to PTPalpha (show PTPRA Antibodies) Tyr789 phosphorylation and mediates Cas (show CTNND1 Antibodies) localization to focal adhesions and Cas (show CTNND1 Antibodies) downstream signaling to promote cell migration

  9. p130Cas phosphorylation, mediated by integrin beta3, facilitates cofilin inactivation and promotes myogenic differentiation through modulating actin cytoskeleton remodelling

  10. Cas (show CTNND1 Antibodies) is required for apoptosis that is induced by proteasome inhibition, and potentially by other death stimuli.

Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) Antigen Profile

Antigen Summary

BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006

Alternative names and synonyms associated with Breast Cancer Anti-Estrogen Resistance 1 (BCAR1)

  • breast cancer anti-estrogen resistance 1 (bcar1) antibody
  • breast cancer anti-estrogen resistance 1 (BCAR1) antibody
  • breast cancer anti-estrogen resistance 1 (Bcar1) antibody
  • breast cancer anti-estrogen resistance 1-like (LOC100350323) antibody
  • AI385681 antibody
  • BCAR1 antibody
  • Cas antibody
  • CAS1 antibody
  • CASS1 antibody
  • CRKAS antibody
  • fc17f11 antibody
  • MGC68466 antibody
  • P130CAS antibody
  • wu:fc17f11 antibody
  • zgc:175192 antibody

Protein level used designations for BCAR1

breast cancer anti-estrogen resistance 1 , breast cancer anti-estrogen resistance protein 1-like , Cas scaffolding protein family member 1 , Crk-associated substrate p130Cas , breast cancer anti-estrogen resistance protein 1 , CRK-associated substrate , p130 Cas , p130cas , v-crk-associated tyrosine kinase substrate

GENE ID SPECIES
398756 Xenopus laevis
415691 Gallus gallus
447979 Xenopus (Silurana) tropicalis
454246 Pan troglodytes
568309 Danio rerio
100391559 Callithrix jacchus
100435586 Pongo abelii
9564 Homo sapiens
12927 Mus musculus
25414 Rattus norvegicus
479648 Canis lupus familiaris
527550 Bos taurus
100127482 Sus scrofa
100350323 Oryctolagus cuniculus
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