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Within the pH range 5.0-11.5, CAMK4 maintained both its secondary and tertiary structures, along with its function, whereas significant aggregation was observed at acidic pH (2.0-4.5).
A positive association was not observed between rs10491334 in the CAMK4 gene and longevity in a Chinese population.
The T-allele of rs10491334 in CAMK4 was associated with hypertension in the Uygur group.
Expression of CaMKIV inhibits autophosphorylation and activation of CaMKII (show CAMK2G ELISA Kits), and elicits G0/G1cell cycle arrest,impairing cell proliferation.
An imbalance of specific isoforms of CYFIP1 (show CYFIP1 ELISA Kits), an FMRP (show FMR1 ELISA Kits) interaction partner, and CAMK4, a transcriptional regulator of the FMRP (show FMR1 ELISA Kits) gene, modulates risk for autism spectrum disorders.
CaMK4-dependent activation of AKT (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) and CREM (show CREM ELISA Kits)-alpha underlies autoimmunity-associated Th17 imbalance.
CaMK4 regulates beta-cell proliferation and apoptosis in a CREB (show CREB1 ELISA Kits)-dependent manner and CaMK4-induced IRS-2 (show IRS2 ELISA Kits) expression is important in these processes
study suggests that the mutations in CAMK4 may lead to abnormal semen parameters
Phosphorylated Notch1 (show NOTCH1 ELISA Kits)-IC by CaMKIV increases Notch1 (show NOTCH1 ELISA Kits)-IC stability, which enhances osteoclast differentiation.
Prolongevity genes are activated by CAMKIV, the levels of which are influenced by rs10491334, a single-nucleotide polymorphism associated with human longevity.
results imply that CaMKIV plays a role in maintenance the structure of chromatoid body by regulating the associations of proteins in it
CaMK4 activity is increased in T cells from systemic lupus erythematosus mice compared with the control group.
Results demonstrated that genetically inhibiting the CaMKK (show CAMKK2 ELISA Kits) pathway via CaMKKbeta or CaMK IV is detrimental in the response of female mice to cerebral ischemia
CaMKIV-mTOR (show FRAP1 ELISA Kits)-dependent autophagy is conserved in both immune and nonimmune/parenchymal cells and is fundamental for the respective functional and adaptive responses to septic insult.
The stimulation of CaMKII (show CAMK2G ELISA Kits) activity in the hippocampus is essential for rivastigmine-induced memory improvement in olfactory bulbectomized mice.
CaMKK (show CAMKK2 ELISA Kits)/CaMK IV pathway is a key endogenous protective mechanism in cerebral ischemia.
CaMKIV has opposing roles in nicotine and cocaine reward.
The reduced fertility of Crybb2 (show CRYbB2 ELISA Kits) knockout male mice may result from the disordered proliferation and apoptosis of germ cells in the testis, possibly due to reduced CaMKIV from the loss of Crybb2 (show CRYbB2 ELISA Kits).
We identified the zebrafish homologue of CaMKIV (zCaMKIV) on the basis of biochemical characterization. zCaMKIV showed similar biochemical properties as well as tissue and subcellular distributions to rat CaMKIV (rCaMKIV)
Data suggest that Tyr (show TYR ELISA Kits)(99) phosphorylated calmodulin (show CALM ELISA Kits), as compared to non-phosphorylated, binds with a higher affinity at the calmodulin (show CALM ELISA Kits) binding site (rich in basic amino acids) of CaM kinase IV leading to increased activation of CaM kinase IV.
conclude that the hypoxia-induced increased activation of CaM kinase IV cascade increases with the increase in the degree of cerebral tissue hypoxia as measured by cerebral tissue high energy phosphates in a curvilinear manner
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.
calcium/calmodulin-dependent protein kinase type IV-like
, calcium/calmodulin-dependent protein kinase IV
, CAM kinase IV
, CAM kinase- GR
, brain Ca(2+)-calmodulin-dependent protein kinase type IV
, brain Ca++-calmodulin-dependent protein kinase type IV
, caM kinase-GR
, calcium/calmodulin-dependent protein kinase type IV
, calcium/calmodulin-dependent protein kinase type IV catalytic chain
, CAM kinase-GR
, Ca2+/calmodulin-dependent protein kinase type IV/Gr
, caMK IV
, Calmodulin-dependent protein kinase IV