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Eps8/Abi1 (show ABI1 ELISA Kits)/Sos1 (show SOS1 ELISA Kits) tricomplex acts as a key molecular switch altering the balance between Rac1 and Rho activation; its presence or absence in pancreatic ductal adenocarcinoma cells modulates alphavbeta6-dependent functions, resulting in a pro-migratory (Rac1-dependent) or a pro-TGF-beta1 (show TGFB1 ELISA Kits) activation (Rho-dependent) functional phenotype
Immunohistochemistry revealed that Eps8 was significantly increased in cervical cancer specimens compared with squamous intraepithelial lesion and normal cervical tissues. Additionally, it was revealed that Eps8 expression not only correlated with cervical cancer progression, but also exhibited a close correlation with the epithelialmesenchymal transition (EMT (show ITK ELISA Kits)) markers, Ecadherin and vimentin (show VIM ELISA Kits).
Eps8 is required for continuous membrane blebbing.
Erk (show EPHB2 ELISA Kits) activity promotes actin bundling by Eps8 to enhance cortex tension and drive the bleb-based migration of cancer cells under non-adhesive confinement.
Eps8 is a crucial mediator of Src (show SRC ELISA Kits)- and FAK (show PTK2 ELISA Kits)-regulated processes.
Eps8 is overexpressed in human breast cancers, possibly by regulating ERK (show EPHB2 ELISA Kits) signaling, MMP9 (show MMP9 ELISA Kits), p53 (show TP53 ELISA Kits) and EMT (show ITK ELISA Kits)-like transition to affect breast cancer cell growth, migration and invasion.
EPS8, as MDR1 and WT1 (show WT1 ELISA Kits), may be a clinically valuable biomarker for assessing the outcome of ALL patients.
These results indicate that employing the native and modified epitopes identified here in Eps8-based immunotherapy for HLA-A2.1 positive cancer patients may result in efficient anticancer immune responses for diverse tumor types.
determined the alpha-synuclein (show SNCA ELISA Kits)-binding domain of beta-III tubulin (show TUBB ELISA Kits) and demonstrated that a short fragment containing this domain can suppress alpha-synuclein (show SNCA ELISA Kits) accumulation in the primary cultured cells
The ITSN2 (show ITSN2 ELISA Kits) interacts with Eps8 and stimulates the degradation of Eps8 proteins.
Absence of Eps8 produces a weaker phenotype in vestibular hair cells compared to cochlear inner hair cells, since it affects the hair bundle morphology but not the basolateral membrane currents. This difference is likely to explain the absence of obvious vestibular dysfunction in Eps8 knockout mice.
Results implicate N-methyl-d-aspartate receptor (show GRIN1 ELISA Kits) hyperfunction in the cognitive deficits observed in Epidermal growth factor receptor (show EGFR ELISA Kits) substrate 8 (Eps8) knockout mice and demonstrate a novel role for Eps8 in regulating hippocampal long-term synaptic plasticity and cognitive function.
These findings demonstrate a novel role for Wnt (show WNT2 ELISA Kits)-Dvl1 (show DVL1 ELISA Kits) signalling through Eps8 in the regulation of axonal remodeling.
It shows that EPS8, a signaling adapter regulating actin dynamics, is a novel partner of VE-cadherin (show CDH5 ELISA Kits) and is able to modulate YAP (show YAP1 ELISA Kits) activity.
The actin-binding proteins eps8 and gelsolin (show GSN ELISA Kits) have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells.
These results reveal a previously unknown cell type-specific expression pattern of endogenous Eps8 protein in the mouse hippocampus.
the key role of Eps8 actin-capping activity in spine morphogenesis and plasticity and indicate that reductions in actin-capping proteins may characterize forms of intellectual disabilities associated with spine defects.
identified Eps8 as a unique actin capping protein (show TMOD4 ELISA Kits) specifically required for Dendritic cell migration
epidermal growth factor receptor pathway substrate 8 is critical in coordinating the development and functionality of mammalian auditory hair cells
critical role for JNK2 (show MAPK9 ELISA Kits) and EPS8 in receptor tyrosine kinase (show ERBB3 ELISA Kits) signaling and trafficking to convey distinctly different effects on cell migration.
the SSC5:60296617 SNP may affect teat number by regulating the interaction of EPS8 and RAPGEF1 (show RAPGEF1 ELISA Kits) and, finally, affecting the mammogenesis of pigs
Coexpression of ezrin with Eps8 promotes the formation of membrane ruffles and tufts of microvilli, whereas expression of ezrin and Eps8L1a induces the clustering of actin-containing structures at the cell surface.
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
epidermal growth factor receptor pathway substrate 8
, epidermal growth factor receptor kinase substrate 8