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STAT3 (show STAT3 ELISA Kits) activation promotes ERBIN expression and negatively regulates TGF-beta (show TGFB1 ELISA Kits) activity by the formation of a STAT3 (show STAT3 ELISA Kits)-ERBIN-SMAD2 (show SMAD2 ELISA Kits)/3 complex.
Study found TMPO (show TMPO ELISA Kits) is significantly upregulated in glioblastoma tissues.TMPO knockdown promoted cell apoptosis by upregulation of the cleavage of caspase-3 (show CASP3 ELISA Kits) and PARP (show COL11A2 ELISA Kits) protein levels.
The findings unveil a unique mechanism where the nuclear periphery proteins lamin-A/C (show LMNA ELISA Kits), LAP2alpha and BAF1 are assembled into a protein complex during mitosis in order to regulate assembly and positioning of the mitotic spindle.
The authors find that LAP2alpha (lamina-associated polypeptide-alpha) interacts with lamin A (show LMNA ELISA Kits), while its interaction with progerin is significantly reduced.
Erbin loss accelerates cell cycle though down-regulating p21 (show CDKN1A ELISA Kits) and p27 (show PAK2 ELISA Kits) expression. Erbin is a novel negative modulator of Akt1 (show AKT1 ELISA Kits)-Skp2-p27 (show PAK2 ELISA Kits) signaling pathway.
Erbin promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor (show EGFR ELISA Kits)
Erbin is an ErbB2 (show ERBB2 ELISA Kits) regulator for breast tumor formation and progression
analysis of the C-terminal ligand specificity of the erbin PDZ domain (show INADL ELISA Kits)
Results highlight the interactions at the nuclear envelope where mutations in the EMD (show EMD ELISA Kits) and TMPO (show TMPO ELISA Kits) gene in combination with mutations in SUN1 (show SUN1 ELISA Kits) have an impact on several components of the network.
Data suggest that Erbin can interact with Sema4C (show SEMA4C ELISA Kits), and co-expression of Erbin blocks the process of Sema4C (show SEMA4C ELISA Kits)-induced epithelial-mesenchymal transition.
Overexpression of FHL2 (show FHL2 ELISA Kits) alone had no effect on Erbin expression, but in the presence of MITF (show MITF ELISA Kits), Erbin expression was decreased.
By degrading Erbin and Nrf2 (show NFE2L2 ELISA Kits), Sag (show RNF7 ELISA Kits) activates the Ras-Raf (show RAF1 ELISA Kits) pathway and causes ROS (show ROS1 ELISA Kits) accumulation to trigger autophagy and senescence
Results support that hyperglycemia may impair NRG1 (show NRG1 ELISA Kits)/Erb (show ESR2 ELISA Kits) B2 signaling by disrupting the balance between NRG1 (show NRG1 ELISA Kits) isoforms, decreasing the expression of erbin and correspondingly activating the MAPK (show MAPK1 ELISA Kits) pathway
Erbin is an inhibitor of pathological cardiac hypertrophy.
Lifespan and body mass were increased in Lmna (show LMNA ELISA Kits)(-/-)Lap2alpha(-/-) mice compared with Lmna (show LMNA ELISA Kits) deficient mice.
Data indicate that a LAP2alpha-independent assembly defect of DeltaK32 lamin A/C (show LMNA ELISA Kits) is the cause of the pathology, whereas the LAP2alpha-linked functions of nucleoplasmic lamin A/C (show LMNA ELISA Kits) in the regulation of tissue progenitor cells are not affected in Lmna (show LMNA ELISA Kits)(DeltaK32/DeltaK32) mice.
These observations demonstrate a crucial function for Erbin in AMPAR surface expression in cortical parvalbumin (show PVALB ELISA Kits) positive interneurons
This study demonistrated that demonstrate that Erbin is required for remyelination of regenerated axons after injury, probably by regulating ErbB2 (show ERBB2 ELISA Kits) and NRG1 (show NRG1 ELISA Kits) levels, identifying a novel player in regulating remyelination.
LAP2alpha serves as a transcriptional co-regulator, which controls muscle specific (show EIF3K ELISA Kits) gene expression during muscle regeneration, muscle remodeling and stress response.
The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
erbb2 interacting protein
, ERBB2 interacting protein
, protein LAP2-like
, densin-180-like protein
, protein LAP2
, erbb2-interacting protein
, LEM domain containing 4
, TP alpha
, TP beta/gamma
, lamina-associated polypeptide 2
, thymopoietin-related peptide isoform alpha
, thymopoietin-related peptide isoforms beta/gamma