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STAT3 (show STAT3 ELISA Kits) activation promotes ERBIN expression and negatively regulates TGF-beta (show TGFB1 ELISA Kits) activity by the formation of a STAT3 (show STAT3 ELISA Kits)-ERBIN-SMAD2 (show SMAD2 ELISA Kits)/3 complex.
Erbin loss accelerates cell cycle though down-regulating p21 (show CDKN1A ELISA Kits) and p27 (show PAK2 ELISA Kits) expression. Erbin is a novel negative modulator of Akt1 (show AKT1 ELISA Kits)-Skp2-p27 (show PAK2 ELISA Kits) signaling pathway.
Erbin promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor (show EGFR ELISA Kits)
Erbin is an ErbB2 (show ERBB2 ELISA Kits) regulator for breast tumor formation and progression
analysis of the C-terminal ligand specificity of the erbin PDZ domain (show INADL ELISA Kits)
Data suggest that Erbin can interact with Sema4C (show SEMA4C ELISA Kits), and co-expression of Erbin blocks the process of Sema4C (show SEMA4C ELISA Kits)-induced epithelial-mesenchymal transition.
Data reveal that Erbin is a negative regulator of AKT (show AKT1 ELISA Kits) activation and suggest that Erbin may play a role in breast cancer progression.
DSG1 (show DSG1 ELISA Kits) and Erbin cooperate to repress MAPK (show MAPK1 ELISA Kits) signaling and promote keratinocyte differentiation.
These results unravel a critical role of c-Myb (show MYB ELISA Kits) in promoting Erbin transcription in G2/M phase and also predict an unappreciated function of Erbin in cell cycle progression.
Data conclude that LAP2 is widely overexpressed in diverse digestive tract cancers and LAP2beta (show TMPO ELISA Kits) regulates motility of cancer cells and suggest that LAP2beta (show TMPO ELISA Kits) may have utility for diagnostics and therapeutics in digestive tract cancers.
Overexpression of FHL2 (show FHL2 ELISA Kits) alone had no effect on Erbin expression, but in the presence of MITF (show MITF ELISA Kits), Erbin expression was decreased.
By degrading Erbin and Nrf2 (show NFE2L2 ELISA Kits), Sag (show RNF7 ELISA Kits) activates the Ras-Raf (show RAF1 ELISA Kits) pathway and causes ROS (show ROS1 ELISA Kits) accumulation to trigger autophagy and senescence
Results support that hyperglycemia may impair NRG1 (show NRG1 ELISA Kits)/Erb (show ESR2 ELISA Kits) B2 signaling by disrupting the balance between NRG1 (show NRG1 ELISA Kits) isoforms, decreasing the expression of erbin and correspondingly activating the MAPK (show MAPK1 ELISA Kits) pathway
Erbin is an inhibitor of pathological cardiac hypertrophy.
These observations demonstrate a crucial function for Erbin in AMPAR surface expression in cortical parvalbumin (show PVALB ELISA Kits) positive interneurons
This study demonistrated that demonstrate that Erbin is required for remyelination of regenerated axons after injury, probably by regulating ErbB2 (show ERBB2 ELISA Kits) and NRG1 (show NRG1 ELISA Kits) levels, identifying a novel player in regulating remyelination.
preliminary characterization of its interaction with Smad3 (show SMAD3 ELISA Kits)
erbin regulates MAP kinase (show MAPK1 ELISA Kits) activation in Schwann cells and suggest that erbin links merlin (show NF2 ELISA Kits) to both adherens junction protein complexes and the MAP kinase (show MAPK1 ELISA Kits) signaling pathway.
Erbin is a regulator of Nod2 (show NOD2 ELISA Kits)-dependent NF-kappaB (show NFKB1 ELISA Kits) signaling with a role in inflammatory responses
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, protein LAP2
, erbb2 interacting protein
, ERBB2 interacting protein
, protein LAP2-like
, erbb2-interacting protein
, similar to Erbb2 interacting protein isoform 2