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Human Polyclonal GPER Primary Antibody for IF, IHC (p) - ABIN271054
Alyea, Laurence, Kim, Katzenellenbogen, Katzenellenbogen, Watson: The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells. in Journal of neurochemistry 2008
Show all 10 Pubmed References
Human Polyclonal GPER Primary Antibody for FACS, ICC - ABIN441270
Tian, Wang, Shi, Li, Wang, Zhu, Lin, Gui, Zheng: Differential expression of G-protein-coupled estrogen receptor-30 in human myometrial and uterine leiomyoma smooth muscle. in Fertility and sterility 2012
Show all 5 Pubmed References
Human Polyclonal GPER Primary Antibody for IF (p), IHC (p) - ABIN685717
Wang, Zhao, Lin, Groban: Activation of GPR30 inhibits cardiac fibroblast proliferation. in Molecular and cellular biochemistry 2015
Show all 3 Pubmed References
Human Polyclonal GPER Primary Antibody for IHC (p), WB - ABIN4315518
Hofmeister, Damkier, Christensen, Olde, Fredrik Leeb-Lundberg, Fenton, Praetorius, Praetorius: 17β-Estradiol induces nongenomic effects in renal intercalated cells through G protein-coupled estrogen receptor 1. in American journal of physiology. Renal physiology 2012
Show all 3 Pubmed References
Human Polyclonal GPER Primary Antibody for IHC (p), WB - ABIN1048791
Vivacqua, Bonofiglio, Recchia, Musti, Picard, Andò, Maggiolini: The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells. in Molecular endocrinology (Baltimore, Md.) 2006
Show all 2 Pubmed References
Dog (Canine) Polyclonal GPER Primary Antibody for IF, IHC (p) - ABIN4315517
Spary, Chapman, Sinfield, Maqbool, Kaye, Batten: Novel G protein-coupled oestrogen receptor GPR30 shows changes in mRNA expression in the rat brain over the oestrous cycle. in Neuro-Signals 2013
Show all 2 Pubmed References
Human Polyclonal GPER Primary Antibody for IF, IHC (p) - ABIN122586
Ignatov, Modl, Thulig, Weißenborn, Treeck, Ortmann, Zenclussen, Costa, Kalinski, Ignatov: GPER-1 acts as a tumor suppressor in ovarian cancer. in Journal of ovarian research 2013
Human Polyclonal GPER Primary Antibody for ELISA, IHC (p) - ABIN271052
Park, Zhang, Liu, Kozlowski, Zhang, Lee: 17Beta-estradiol at low concentrations acts through distinct pathways in normal versus benign prostatic hyperplasia-derived prostate stromal cells. in Endocrinology 2009
Human Polyclonal GPER Primary Antibody for WB - ABIN1537181
Altmann, Yan, Meeks, Abood, Brailoiu, Brailoiu: G protein-coupled estrogen receptor-mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells. in Journal of neurochemistry 2015
PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1
Estradiol can weakly modulate the motility and this effect is strictly associated with GPER and not with ESR1 (show ESR1 Antibodies) and ESR2 (show ESR2 Antibodies). The subcellular localization of GPER in the neck on stallion sperm is coherent with this effect.
The presence of a single isoform of ESR1 (show ESR1 Antibodies) (66kDa (show SF3A2 Antibodies)) and ESR2 (show ESR2 Antibodies) (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.
The intron variant rs4265085 of GPER1 may confer risk for recurrent spontaneous abortion in Dai and Bai ethnic groups in China.
Activation of GPER can suppress migration and angiogenesis of triple negative breast cancer by inhibiting of NF-kappaB (show NFKB1 Antibodies)/IL-6 (show IL6 Antibodies) signaling.
GPER protects against hepatic tumorigenesis by regulating inflammatory responses.
GPER enhances melanogenesis via PKA by upregulating microphthalmia-related transcription factor-tyrosinase (show TYR Antibodies) in melanoma
Data suggest that GPR30 increases ERK1/2 activity via two Gi/o-mediated mechanisms, a PDZ-dependent constitutive mechanism and a PDZ-independent Gi/o-stimulated mechanism involving PI3K. (GPR30 = G protein-coupled estrogen receptor 1; ERK1 = extracellular signal-regulated kinase 1; ERK2 = extracellular signal-regulated kinase 2; Gi/0 = GTP-binding protein alpha subunits, Gi-Go; PI3K = phosphoinositide-3-kinase)
present study revealed that BPA (show DST Antibodies) can trigger the progression of laryngeal squamous cell carcinoma via GPER-mediated upregulation of IL-6 (show IL6 Antibodies). Therefore, more attention should be paid for the BPA (show DST Antibodies) exposure on the development of laryngeal cancer.
G protein-coupled estrogen receptor (show ESR1 Antibodies) stabilizes HIF-1alpha (show HIF1A Antibodies) and thus promotes HIF-1alpha (show HIF1A Antibodies)-induced VEGF (show VEGFA Antibodies) and MMP9 (show MMP9 Antibodies) in endometrial stromal cells, which play critical roles in endometriosis.
GPR30 activation by G-1 interfered expression of cell cycle regulators and machinery elements to modulate prostate cancer cell growth
A novel mechanism whereby GPR30 limits ERalpha (show ESR1 Antibodies) expression via inhibition of the cAMP/protein kinase A signaling pathway. This suggests that stem-like cells within the stroma are a possible source of prostate Cancer-associated fibroblasts and that the negative regulation of ERalpha (show ESR1 Antibodies) expression by GPR30 is centrally involved in prostate stromal cell activation.
These results provide evidence that (1) GPR30 is involved in regulating cell proliferation and apoptosis; (2) pharmacologic upregulation of GPR30 is beneficial for preeclampsia (PE) management; (3) GPR30 may therefore be an interventional target for pregnancies complicated by PE.
These findings provide strong evidence for aldosterone serving a causal role in renal cell cancer regulation via its GPER receptor; thus, antagonism of GPER represents a potential new target for treatment to reduce metastatic spread.
Data suggest that prenatal exposure to p,p'-DDT (show DDT Antibodies) (an endocrine disrupting pesticide) causes sex- and age-independent attenuation of Gper1 in brain which appears to play key role in propagation of DDT (show DDT Antibodies)-induced depressive-like neurotoxicity.
Study suggested that the neuroprotective effect of estrogen requires intact GPER1-associated signaling in an in vitro model of ischemia. The membrane-associated signaling mediates the estrogen actions, and depends on PI3K/Akt (show AKT1 Antibodies) signaling for Ask1 (show MAP3K5 Antibodies) inhibition that prevents the cell death triggered by ischemia. These mechanisms may help for a therapeutic strategy to target on GPER1 for the treatment of neurological disorders.
Phosphorylation of myosin regulatory light chain triggered by E2 was found to be mediated by estrogen receptor-beta (show ESR2 Antibodies) and the G protein-coupled estrogen receptor (show ESR1 Antibodies).
Our study demonstrated the ameliorative role of GPR30 in NOR memory impaired by AD pathology in female mice
identified a novel regulatory mechanism through which the endogenous Gper facilitates the age-dependent increase in myocardial expression of ECE-2 (show ECE2 Antibodies) and the ETB (show EDNRB Antibodies) receptor, which is compatible with an activating role of GPER for the local endothelin system with aging
We suggest that activation of GPER exerts an inhibitory effect on colonic motility by promoting nitric oxide release from myenteric nitrergic nerves
GPR30 is expressed in diverse intracellular compartments in undifferentiated and differentiated C2C12 cells and mediates estradiol actions.
Results demonstrate that ERalpha (show ESR1 Antibodies), ERbeta (show ESR2 Antibodies), and GPER1 all participate in the rapid effects of 17beta-estradiol-3-benzoate on hippocampal synaptic function
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.
G protein-coupled estrogen receptor 1
, G-protein coupled estrogen receptor 1-like
, G protein-coupled receptor 30
, G-protein coupled estrogen receptor 1
, G-protein coupled receptor 30
, IL8-related receptor DRY12
, chemoattractant receptor-like 2
, chemokine receptor-like 2
, constitutively expressed peptide-like receptor
, flow-induced endothelial G-protein coupled receptor 1
, heptahelix receptor
, leucine rich protein in GPR30 3'UTR
, lymphocyte-derived G-protein coupled receptor
, membrane estrogen receptor
, constitutively expressed peptide-like receptor like
, G-protein coupled receptor 41