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Results demonstrate the existence of crosstalk between beta-catenin signaling and HGS in two different types of cancer (hepatoblastoma and colorectal).
ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM (show STAM Proteins)) and the complex formation with STAM (show STAM Proteins) promotes its endosomal dissociation.
we identified an interaction between EsxH, which is secreted by the Esx-3 TSSS, and human hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs), a component of the endosomal sorting complex required for transport (ESCRT).
the role for tumoral c-Met expression or sMet/HGF (show HGF Proteins) levels as upfront selection criterion or predictive biomarkers deserve further study in this emerging area of therapeutic focus in RCC (show XRCC1 Proteins)
Hrs tyrosine phosphorylation detected upon EGF (show EGF Proteins)-stimulation.
Hrs inhibits HIV-1 production by inhibiting citron kinase (show CIT Proteins)-mediated exocytosis.
ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin (show BST2 Proteins) down-regulation.
Plasma hepatocyte growth factor (show HGF Proteins) is associated with periampullary cancer.
hSpry2 binds to the endocytic regulatory protein, hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) and blocks intracellular signal propagation.
The HRS domain required for merlin (show NF2 Proteins) binding is narrowed to a region (residues 470-497) containing the predicted coiled-coil domain whereas the major domain responsible for HRS growth suppression is distinct (residues 498-550).
structure of a complex of Hrs-UIM and ubiquitin at 1.7-A resolution [ubiquitin]
HGS expression in the nervous system is developmentally regulated.HGS is required for motor neuron function.
Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.
A new mechanism to modify BMP signaling by Hgs during early mouse development.
Hrs is a master molecule that controls in part the degradation of STAM1 (show STAM Proteins) and the accumulation of ubiquitinated proteins
Data suggest that Hrs regulates the KGFR (show FGFR2 Proteins) degradative pathway, but not its juxtanuclear recycling transport, and that Hrs recruitment to the receptor, but not its ligand-induced phosphorylation, could be required for its function.
Nedd4-2 (show NEDD4L Proteins) induces binding of ENaC (show SCNN1A Proteins) to Hrs, which mediates the sorting decision between ENaC (show SCNN1A Proteins) degradation and recycling.
Peptidergic versus nonpeptidergic specification depends on a balance between HGF (show HGF Proteins)-Met signaling and Runx1 (show RUNX1 Proteins) extinction/maintenance in primary nociceptive neurons.
Src (show SRC Proteins) phosphorylates Hrs in vitro & in vivo. Hrs is phosphorylated in Src (show SRC Proteins)-, Yes- & Fyn (show FYN Proteins)-negative cells. 10-20% is phosphorylated after EGF (show EGF Proteins) stimulation at multiple tyrosines in different parts of Hrs by several kinases downstream of the EGF receptor (show EGFR Proteins).
Hrs, Eps15 (show EPS15 Proteins), and STAM (show STAM Proteins) proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.
These results reveal that ESCRT-0 (ESCRT-0 components stam (show STAM Proteins) and hrs)mutants inhibit EGFR (show EGFR Proteins) signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
Hrs is dispensable for cytokinesis. Finally, it was found that although Drosophila Hrs does not localize at acrosome, the other endosomal markers--Rab4, Rab7, and Rab11--are detected at the organelle.
Drosophila epithelia lacking Hrs and Stam (show STAM Proteins), accumulate Notch (show NOTCH1 Proteins) and Dome in endosomes, maintain normal apico-basal polarity and proliferation control and do not show ectopic Notch (show NOTCH1 Proteins) signaling activation.
Hrs mediates Smo trafficking in the late endosome by not only promoting Smo ubiquitination but also blocking Smo phosphorylation.
these data support a model in which Ubpy (show USP8 Proteins) plays a dual role in both cargo deubiquitylation and the ESCRT-0 subunit Hrs stability during development.
show that the endosomal proteins Myopic (Mop (show OPN4 Proteins)) and Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) are required for the activation of the Toll (show TLR4 Proteins) signaling pathway.
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.
human growth factor-regulated tyrosine kinase substrate
, protein pp110
, HGF-regulated tyrosine kinase substrate
, SNAP-25-interacting protein Hrs-2
, hepatocyte growth factor-regulated tyrosine kinase substrate
, hepatocyte growth factor regulated tyrosine kinase
, hepatocyte growth factor regulated tyrosine kinase substrate
, hepatocyte growth-factor-regulated substrate
, hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog