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Browse our HGS Proteins (HGS)

Full name:
Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate Proteins (HGS)
On www.antibodies-online.com are 6 Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) Proteins from 4 different suppliers available. Additionally we are shipping HGS Antibodies (113) and HGS Kits (9) and many more products for this protein. A total of 134 HGS products are currently listed.
Synonyms:
CG2903, Dmel\\CG2903, Hgr, Hrs, HRS-2, l(2)23AB5, l(2)23Ad, l(2)23Ad(Hrs), vps27, ZFYVE8
list all proteins Gene Name GeneID UniProt
HGS 9146 O14964
HGS 56084 Q9JJ50
HGS 15239 Q99LI8

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HGS Proteins (HGS) by Origin

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More Proteins for HGS Interaction Partners

Fruit Fly (Drosophila melanogaster) Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) interaction partners

  1. Hrs is dispensable for cytokinesis. Finally, it was found that although Drosophila Hrs does not localize at acrosome, the other endosomal markers--Rab4, Rab7, and Rab11--are detected at the organelle.

  2. Drosophila epithelia lacking Hrs and Stam (show STAM Proteins), accumulate Notch (show NOTCH1 Proteins) and Dome in endosomes, maintain normal apico-basal polarity and proliferation control and do not show ectopic Notch (show NOTCH1 Proteins) signaling activation.

  3. Hrs mediates Smo trafficking in the late endosome by not only promoting Smo ubiquitination but also blocking Smo phosphorylation.

  4. these data support a model in which Ubpy (show USP8 Proteins) plays a dual role in both cargo deubiquitylation and the ESCRT-0 subunit Hrs stability during development.

  5. show that the endosomal proteins Myopic (Mop (show OPN4 Proteins)) and Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) are required for the activation of the Toll (show TLR4 Proteins) signaling pathway.

Human Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) interaction partners

  1. Results demonstrate the existence of crosstalk between beta-catenin signaling and HGS in two different types of cancer (hepatoblastoma and colorectal).

  2. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM (show STAM Proteins)) and the complex formation with STAM (show STAM Proteins) promotes its endosomal dissociation.

  3. we identified an interaction between EsxH, which is secreted by the Esx-3 TSSS, and human hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs), a component of the endosomal sorting complex required for transport (ESCRT).

  4. the role for tumoral c-Met expression or sMet/HGF (show HGF Proteins) levels as upfront selection criterion or predictive biomarkers deserve further study in this emerging area of therapeutic focus in RCC (show XRCC1 Proteins)

  5. Hrs tyrosine phosphorylation detected upon EGF (show EGF Proteins)-stimulation.

  6. Hrs inhibits HIV-1 production by inhibiting citron kinase (show CIT Proteins)-mediated exocytosis.

  7. ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin (show BST2 Proteins) down-regulation.

  8. Plasma hepatocyte growth factor (show HGF Proteins) is associated with periampullary cancer.

  9. hSpry2 binds to the endocytic regulatory protein, hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) and blocks intracellular signal propagation.

  10. The HRS domain required for merlin (show NF2 Proteins) binding is narrowed to a region (residues 470-497) containing the predicted coiled-coil domain whereas the major domain responsible for HRS growth suppression is distinct (residues 498-550).

Cow (Bovine) Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) interaction partners

  1. structure of a complex of Hrs-UIM and ubiquitin at 1.7-A resolution [ubiquitin]

Mouse (Murine) Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) interaction partners

  1. HGS expression in the nervous system is developmentally regulated.HGS is required for motor neuron function.

  2. Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.

  3. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM (show STAM Proteins)) and the complex formation with STAM (show STAM Proteins) promotes its endosomal dissociation.

  4. A new mechanism to modify BMP signaling by Hgs during early mouse development.

  5. Hrs is a master molecule that controls in part the degradation of STAM1 (show STAM Proteins) and the accumulation of ubiquitinated proteins

  6. Data suggest that Hrs regulates the KGFR (show FGFR2 Proteins) degradative pathway, but not its juxtanuclear recycling transport, and that Hrs recruitment to the receptor, but not its ligand-induced phosphorylation, could be required for its function.

  7. Nedd4-2 (show NEDD4L Proteins) induces binding of ENaC (show SCNN1A Proteins) to Hrs, which mediates the sorting decision between ENaC (show SCNN1A Proteins) degradation and recycling.

  8. Peptidergic versus nonpeptidergic specification depends on a balance between HGF (show HGF Proteins)-Met signaling and Runx1 (show RUNX1 Proteins) extinction/maintenance in primary nociceptive neurons.

  9. Src (show SRC Proteins) phosphorylates Hrs in vitro & in vivo. Hrs is phosphorylated in Src (show SRC Proteins)-, Yes- & Fyn (show FYN Proteins)-negative cells. 10-20% is phosphorylated after EGF (show EGF Proteins) stimulation at multiple tyrosines in different parts of Hrs by several kinases downstream of the EGF receptor (show EGFR Proteins).

  10. Hrs, Eps15 (show EPS15 Proteins), and STAM (show STAM Proteins) proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.

HGS Protein Profile

Protein Summary

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.

Alternative names and synonyms associated with HGS

  • Hepatocyte growth factor regulated tyrosine kinase substrate (Hrs)
  • hepatocyte growth factor-regulated tyrosine kinase substrate (HGS)
  • hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs)
  • HGF-regulated tyrosine kinase substrate (Hgs)
  • CG2903 protein
  • Dmel\\CG2903 protein
  • Hgr protein
  • Hrs protein
  • HRS-2 protein
  • l(2)23AB5 protein
  • l(2)23Ad protein
  • l(2)23Ad(Hrs) protein
  • vps27 protein
  • ZFYVE8 protein

Protein level used designations for HGS

CG2903-PA , CG2903-PB , CG2903-PC , Hrs-PA , Hrs-PB , Hrs-PC , hepatocyte growth factor regulated tyrosine kinase , hepatocyte growth factor regulated tyrosine kinase substrate , hepatocyte growth factor-regulated tyrosine kinase substrate , hepatocyte growth-factor-regulated substrate , human growth factor-regulated tyrosine kinase substrate , protein pp110 , HGF-regulated tyrosine kinase substrate , SNAP-25-interacting protein Hrs-2

GENE ID SPECIES
33458 Drosophila melanogaster
9146 Homo sapiens
56084 Rattus norvegicus
511582 Bos taurus
15239 Mus musculus
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