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anti-Human Mesothelin Antibodies:
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Human Monoclonal Mesothelin Primary Antibody for IHC (p), IHC - ABIN259911
Ho, Bera, Willingham, Onda, Hassan, FitzGerald, Pastan: Mesothelin expression in human lung cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007
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Human Monoclonal Mesothelin Primary Antibody for FACS - ABIN4897254
Cherkassky, Morello, Villena-Vargas, Feng, Dimitrov, Jones, Sadelain, Adusumilli: Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition. in The Journal of clinical investigation 2016
Show all 2 Pubmed References
Human Polyclonal Mesothelin Primary Antibody for IHC, IHC (p) - ABIN4333902
Feng, Zhang, Anver, Hassan, Ho: In vivo imaging of human malignant mesothelioma grown orthotopically in the peritoneal cavity of nude mice. in Journal of Cancer 2011
Show all 2 Pubmed References
Human Monoclonal Mesothelin Primary Antibody for IHC, WB - ABIN233753
Xiang, Phung, Feng, Nagashima, Zhang, Broaddus, Hassan, Fitzgerald, Ho: The Development and Characterization of a Human Mesothelioma In Vitro 3D Model to Investigate Immunotoxin Therapy. in PLoS ONE 2011
Human Monoclonal Mesothelin Primary Antibody for FACS - ABIN4897252
Takenouchi, Hirai, Sakuragi, Yagita, Hamada, Kato: Epigenetic modulation enhances the therapeutic effect of anti-IL-13R(alpha)2 antibody in human mesothelioma xenografts. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Human Monoclonal Mesothelin Primary Antibody for FACS - ABIN4897250
Servais, Suzuki, Colovos, Rodriguez, Sima, Fleisher, Rusch, Sadelain, Adusumilli: An in vivo platform for tumor biomarker assessment. in PLoS ONE 2011
Human Polyclonal Mesothelin Primary Antibody for ELISA, WB - ABIN4333900
Cheng, Huang, Chang, Hu, Chiang, Chen, Hsieh, Chen: High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma. in British journal of cancer 2009
These clinical data showed that the expression of G-protein coupled estrogen receptor (show ESR1 Antibodies) (GPER (show GPER Antibodies)) is negatively associated with lymph node metastasis, high-grade tumor and fibronectin (FN (show FN1 Antibodies)) expression while positively associated with the favorable outcome in 135 triple negative breast cancer cells patients.
Data suggest that, under agonism of estrogens, ESR1 (show ESR1 Antibodies) exhibits a generally anxiogenic effect, ESR2 (show ESR2 Antibodies) exhibits a generally anxiolytic effect, and GPR30 (show GPER Antibodies) exhibits both anxiogenic and anxiolytic effects. (ESR1 (show ESR1 Antibodies) = estrogen receptor 1/alpha (show ESR1 Antibodies); ESR2 (show ESR2 Antibodies) = estrogen receptor 2/beta (show ESR2 Antibodies); GPR30 (show GPER Antibodies) = G protein-coupled estrogen receptor 1 (show GPER Antibodies)) [REVIEW]
Either by specific inhibitors for GPER (show GPER Antibodies), ERK (show EPHB2 Antibodies), AKT (show AKT1 Antibodies) and NF-kappaB (show NFKB1 Antibodies), or by knock-down of GPER (show GPER Antibodies).
The intron variant rs4265085 of GPER1 may confer risk for recurrent spontaneous abortion in Dai and Bai ethnic groups in China.
Mesothelin/mucin 16 (show MUC16 Antibodies) signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.(
MiR (show MLXIP Antibodies)-21-5p is suggested as novel regulator of MSLN with a possible functional role in cellular growth.
Activation of GPER (show GPER Antibodies) can suppress migration and angiogenesis of triple negative breast cancer by inhibiting of NF-kappaB (show NFKB1 Antibodies)/IL-6 (show IL6 Antibodies) signaling.
we report herein that high tumor mesothelin expression predicts a shorter PFS and OS in EOC patients and demonstrates that serum mesothelin predicts local tumor mesothelin expression.
GPER (show GPER Antibodies) protects against hepatic tumorigenesis by regulating inflammatory responses.
We provide new evidence for the role of MSLN in EMT (show ITK Antibodies) regulation, tumorigenesis and metastasis. Knockdown of MSLN led to mesenchymal to epithelial transition and less aggressive behavior of lung carcinoma and mesothelioma cells.
These findings provide strong evidence for aldosterone serving a causal role in renal cell cancer regulation via its GPER (show GPER Antibodies) receptor; thus, antagonism of GPER (show GPER Antibodies) represents a potential new target for treatment to reduce metastatic spread.
Data suggest that prenatal exposure to p,p'-DDT (show DDT Antibodies) (an endocrine disrupting pesticide) causes sex- and age-independent attenuation of Gper1 in brain which appears to play key role in propagation of DDT (show DDT Antibodies)-induced depressive-like neurotoxicity.
Study suggested that the neuroprotective effect of estrogen requires intact GPER1-associated signaling in an in vitro model of ischemia. The membrane-associated signaling mediates the estrogen actions, and depends on PI3K/Akt (show AKT1 Antibodies) signaling for Ask1 (show MAP3K5 Antibodies) inhibition that prevents the cell death triggered by ischemia. These mechanisms may help for a therapeutic strategy to target on GPER1 for the treatment of neurological disorders.
Phosphorylation of myosin regulatory light chain triggered by E2 was found to be mediated by estrogen receptor-beta (show ESR2 Antibodies) and the G protein-coupled estrogen receptor (show ESR1 Antibodies).
Our study demonstrated the ameliorative role of GPR30 (show GPER Antibodies) in NOR memory impaired by AD pathology in female mice
identified a novel regulatory mechanism through which the endogenous Gper (show GPER Antibodies) facilitates the age-dependent increase in myocardial expression of ECE-2 (show ECE2 Antibodies) and the ETB (show EDNRB Antibodies) receptor, which is compatible with an activating role of GPER (show GPER Antibodies) for the local endothelin system with aging
We suggest that activation of GPER (show GPER Antibodies) exerts an inhibitory effect on colonic motility by promoting nitric oxide release from myenteric nitrergic nerves
GPR30 (show GPER Antibodies) is expressed in diverse intracellular compartments in undifferentiated and differentiated C2C12 cells and mediates estradiol actions.
This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.
, megakaryocyte potentiating factor
, pre-pro-megakaryocyte-potentiating factor
, soluble MPF mesothelin related protein
, G protein-coupled receptor 30
, G-protein coupled estrogen receptor 1
, G-protein coupled receptor 30
, chemoattractant receptor-like 2
, constitutively expressed peptide-like receptor like
, membrane estrogen receptor
, protein expressed in renal carcinoma