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anti-Rat (Rattus) PTK2B Antibodies:
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Human Monoclonal PTK2B Primary Antibody for ICS - ABIN1177156
Anand, Cucchiarini, Terwilliger, Ganju: The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Human Monoclonal PTK2B Primary Antibody for ICS - ABIN1177155
Avraham, Park, Schinkmann, Avraham: RAFTK/Pyk2-mediated cellular signalling. in Cellular signalling 2000
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Human Monoclonal PTK2B Primary Antibody for IHC, ELISA - ABIN1724705
Dylla, Deyle, Theunissen, Padurean, Verfaillie: Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. in Experimental hematology 2004
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Human PTK2B Primary Antibody for IHC - ABIN966926
Gluck: Acid sensing in renal epithelial cells. in The Journal of clinical investigation 2004
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Human Polyclonal PTK2B Primary Antibody for IF, IHC - ABIN362858
Benzing, Gerke, Höpker, Hildebrandt, Kim, Walz: Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. in Proceedings of the National Academy of Sciences of the United States of America 2001
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Human Polyclonal PTK2B Primary Antibody for IF, IHC - ABIN362252
Tomomura, Hasegawa, Suda, Sakagami, Tomomura et al.: Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ... in The Journal of biological chemistry 2012
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Human Polyclonal PTK2B Primary Antibody for ICC, IF - ABIN257536
Lu, Chen, Shimoda, Park, Zhang, Tran, Zhang, Semenza: Chemotherapy-Induced Ca(2+) Release Stimulates Breast Cancer Stem Cell Enrichment. in Cell reports 2017
Human Polyclonal PTK2B Primary Antibody for IF (p), IHC (p) - ABIN745118
Cao, Zheng, Wang, Wang, Li, Li, Lai, Wang, Qin: Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. in Bone 2015
Human Monoclonal PTK2B Primary Antibody for IHC, ELISA - ABIN966925
: Fresh concepts in dental design. in Journal of the California Dental Association 2004
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Tideglusib significantly reduced cerebral infarct volume at both 24h and 7days after HI injury. Tideglusib also increased phosphorylated GSK-3beta (show GSK3b Antibodies)(Ser9) and Akt (show AKT1 Antibodies)(Ser473)
Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT (show AKT1 Antibodies)/GSK3beta (show GSK3b Antibodies) signaling axis at cilia in SHH (show SHH Antibodies)-dependent medulloblastoma that is regulated by INPP5E (show INPP5E Antibodies) to maintain tumor cell cilia, promote SHH (show SHH Antibodies) signaling and thereby medulloblastoma progression.
mTORC2 (show CRTC2 Antibodies) complex is responsible for phosphorylating Akt (show AKT1 Antibodies) at S(473).
FHL2 (show FHL2 Antibodies) facilitates ovarian granulosa cell tumor progression via controlling AKT1 (show AKT1 Antibodies) transcription.
Omentin (show ITLN1 Antibodies) protects against lipopysaccharides-induced acute respiratory distress syndrome through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt (show AKT1 Antibodies)/NOS3 (show NOS3 Antibodies)-dependent mechanism.
AIM2 (show AIM2 Antibodies) contributes to the maintenance of intestinal integrity via Akt (show AKT1 Antibodies) and protects against Salmonella mucosal infection.
Following transepithelial migration, neutrophils adhesion to ICAM-1 (show ICAM1 Antibodies) resulted in activation of Akt (show AKT1 Antibodies) and beta-catenin (show CTNNB1 Antibodies) signaling, increased epithelial-cell proliferation, and wound healing.
Besides, both in vivo and in votro studies suggested that K145 stimulated insulin (show INS Antibodies) dependent Akt (show AKT1 Antibodies) phosphorylation and subsequently activates FoxO1 (show FOXO1 Antibodies) phosphorylation therefore inhibited gluconeogenetic genes expression including PEPCK (show PEPCK Antibodies) and G6pase (show G6PC Antibodies). Our study figures out a potential extent increase the value of developing K145 as therapeutic candidate for diabetes.
C5a in vitro caused activation (phosphorylation) of MAPKs and Akt (show AKT1 Antibodies) in cardiomyocytes, which required availability of both C5a receptors. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt (show AKT1 Antibodies) in heart.
High Akt1 (show AKT1 Antibodies) expression is associated with hepatocarcinogenesis.
Our findings suggest that Pyk2 plays an important role in the coordination of stabilization of beta-catenin (show CTNNB1 Antibodies) in the crosstalk between Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and Wnt (show WNT2 Antibodies)/Ca(2 (show CA2 Antibodies)+) signaling pathways upon Wnt3a (show WNT3A Antibodies) stimulation in differentiating hNPCs.
STIM1 (show STIM1 Antibodies)-induced Ca(2 (show CA2 Antibodies)+) signaling activates Pyk2 to inhibit the interaction of VE-PTP (show PTPRB Antibodies) and VE-cadherin (show CDH5 Antibodies) and hence increase endothelial permeability.
Ascites and CCL18 (show CCL18 Antibodies) stimulate the phosphorylation and expression of Pyk2, which positively regulates ascites-induced ovarian cancer cell migration.
We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin, a process in part mediated through the PI3-kinase (show PIK3CA Antibodies)-Akt/PKB (show AKT1 Antibodies) cell survival pathway. These results provide further rationale for clinical investigation of relaxin as a potential therapeutic in preeclampsia.
PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.
Studies suggest that PYK2 is a common downstream effector of ErbB (show EGFR Antibodies) and IL8 (show IL8 Antibodies) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.
Pyk2 is a key downstream signaling molecules of CCR7 (show CCR7 Antibodies) in SCCHN, which promotes SCCHN tumorigenesis and progression.
Phosphoproteomic analysis identifies FAK2 as a potential therapeutic target for tamoxifen resistance in breast cancer.
Pyk2-focal adhesion targeting domain interacts with and binds to leupaxin (show LPXN Antibodies).
Src (show SRC Antibodies) has a role in priming Pyk2 (but not FAK (show PTK2 Antibodies)) phosphorylation and subsequent activation downstream of integrins
Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
, PKB alpha
, RAC protein kinase alpha RAC-PK alpha
, RAC-alpha serine/threonine-protein kinase
, murine thymoma viral (v-akt) oncogene homolog 1
, protein kinase B alpha
, thymoma viral proto-oncogene 1
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, FADK 2
, PTK2B protein tyrosine kinase 2 beta
, calcium-dependent tyrosine kinase
, calcium-regulated non-receptor proline-rich tyrosine kinase
, cell adhesion kinase beta
, focal adhesion kinase 2
, proline-rich tyrosine kinase 2
, protein kinase B
, protein-tyrosine kinase 2-beta
, related adhesion focal tyrosine kinase
, CAK beta
, PTK2 protein tyrosine kinase 2 beta
, cellular adhesion kinase beta
, protein tyrosine kinase 2 beta