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Browse our PTPN2 Proteins (PTPN2)

Full name:
Protein tyrosine Phosphatase, Non-Receptor Type 2 Proteins (PTPN2)
On www.antibodies-online.com are 11 Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) Proteins from 7 different suppliers available. Additionally we are shipping PTPN2 Antibodies (66) and PTPN2 Kits (2) and many more products for this protein. A total of 94 PTPN2 products are currently listed.
Synonyms:
AI325124, cb806, PTN2, PTP-1B, ptpn2, ptpn2l, Ptpt, TC-PTP, TCELLPTP, TCPTP, wu:fc10h07, zgc:55339, zgc:76973
list all proteins Gene Name GeneID UniProt
PTPN2 5771 P17706
PTPN2 19255 Q06180
PTPN2 117063 P35233

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PTPN2 Proteins (PTPN2) by Origin

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Top referenced PTPN2 Proteins

  1. Mouse (Murine) PTPN2 Protein expressed in Baculovirus infected Insect Cells - ABIN2008314 : Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: Lysine acetylation targets protein complexes and co-regulates major cellular functions. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 3 references for ABIN2008314

  2. Human PTPN2 Protein expressed in Baculovirus infected Insect Cells - ABIN2003078 : Iversen, Moller, Pedersen, Peters, Petersen, Andersen, Branner, Mortensen, Moller: Structure determination of T cell protein-tyrosine phosphatase. in The Journal of biological chemistry 2002 (PubMed)
    Show all 3 references for ABIN2003078

More Proteins for PTPN2 Interaction Partners

Human Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) interaction partners

  1. The results suggest that miR (show MLXIP Proteins)-448 might promote Th17 differentiation in multiple sclerosis and thus aggravate the disease through inhibiting PTPN2.

  2. ACPA (show PRTN3 Proteins) were associated significantly with rs7574865 in STAT-4 (show STAT4 Proteins). The SNP rs2233945 in the PSORS1C1 (show PSORS1C1 Proteins) gene was protective regarding the presence of bone erosions, while rs2542151 in PTPN2 gene was associated with joint damage.

  3. Inflammatory bowel disease patients carrying the C-allele of PTPN2 SNP rs1893217 are at greater risk for developing a severe disease course but are more likely to respond to treatment with anti-TNF (show TNF Proteins) antibodies.

  4. The increase in miR (show MLXIP Proteins)-210 resulted in down regulation of its target PTPN2 mRNA in pre-eclampsia.

  5. role of PTPN2 in type 1 diabetes and Crohn's disease (review)

  6. rs2542151 SNP in The PTPN2 gene is associated with T1DM in Chinese Han children

  7. Loss of protein tyrosine phosphatase (show ACP1 Proteins), non-receptor type 2 is associated with activation of AKT (show AKT1 Proteins) and tamoxifen resistance in breast cancer.

  8. Angiopoietin-1 (show ANGPT1 Proteins) Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin (show OCLN Proteins)

  9. dysfunction of PTPN2 results in aberrant T-cell differentiation and intestinal dysbiosis similar to those observed in human CD. Our findings indicate a novel and crucial role for PTPN2 in chronic intestinal inflammation.

  10. PTPN2 is linked to the pathogenesis of rheumatoid arthritis via synovial fibroblasts. It is a regulator of lnterleukin-6 production in rheumatoid arthritis synovial fibroblasts.

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) interaction partners

  1. Loss of PTPN2 in intestinal epithelial cells has no significant influence on inflammation in dextran sulphate sodium-induced colitis. On the other hand, loss of PTPN2 induced enhanced epithelial cell proliferation and promoted wound closure.

  2. Antigen receptor-mediated depletion of FOXP3 (show FOXP3 Proteins) in induced regulatory T-lymphocytes via PTPN2 and FOXO1 (show FOXO1 Proteins)

  3. A novel role for TCPTP in insulin (show INS Proteins) secretion and uncover STAT3 (show STAT3 Proteins) as a physiologically relevant target for TCPTP in the endocrine pancreas.

  4. dysfunction of PTPN2 results in aberrant T-cell differentiation and intestinal dysbiosis similar to those observed in human CD. Our findings indicate a novel and crucial role for PTPN2 in chronic intestinal inflammation.

  5. PTPN2 attenuates T-cell lymphopenia-induced proliferation.

  6. demonstrate that SIPAR (show FAM220A Proteins) directly interacts with T cell protein tyrosine phosphatase TC45 and enhances its association with STAT3 (show STAT3 Proteins)

  7. findings reveal a mechanism by which PTPN2 SNPs might convert a tolerogenic CD8 (show CD8A Proteins)(+) T cell response into one capable of causing the destruction of pancreatic beta-cells.

  8. TC-PTP inhibits STAT3 (show STAT3 Proteins)-mediated mouse keratinocyte skin cell proliferation and survival following UVB irradiation.

  9. Data suggest that spermidine supplementation and subsequent protein tyrosine phosphatase non-receptor type 2 (PTPN2) activation may be helpful in the treatment of chronic intestinal inflammation.

  10. cleavage of TCPTP by NS3 (show MAL Proteins)/4A induces a shift of the intrahepatic immune response toward a nonantiviral Th2-dominated immunity. These effects are reversed by ribavirin.

PTPN2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.

Alternative names and synonyms associated with PTPN2

  • protein tyrosine phosphatase, non-receptor type 2 (ptpn2)
  • protein tyrosine phosphatase, non-receptor type 2 (PTPN2)
  • protein tyrosine phosphatase, non-receptor type 2 (Ptpn2)
  • protein tyrosine phosphatase, non-receptor type 2, b (ptpn2b)
  • AI325124 protein
  • cb806 protein
  • PTN2 protein
  • PTP-1B protein
  • ptpn2 protein
  • ptpn2l protein
  • Ptpt protein
  • TC-PTP protein
  • TCELLPTP protein
  • TCPTP protein
  • wu:fc10h07 protein
  • zgc:55339 protein
  • zgc:76973 protein

Protein level used designations for PTPN2

T-cell protein tyrosine phosphatase , tyrosine-protein phosphatase non-receptor type 2 , MPTP , T cell protein-tyrosine phosphatase , protein-tyrosine phosphatase PTP-2 , protein-tyrosine phosphatase PTP-S , phosphoprotein phosphatase , protein tyrosine phosphatase 1B , protein tyrosine phosphatase, non-receptor type 2, like

GENE ID SPECIES
446745 Xenopus laevis
5771 Homo sapiens
490563 Canis lupus familiaris
540888 Bos taurus
19255 Mus musculus
117063 Rattus norvegicus
396409 Gallus gallus
561613 Danio rerio
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