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Data show that the intracellular domain of PAPC interacts with Sprouty (Spry), and upon binding to PAPC, Spry function is inhibited and PCP signaling is enhanced.
Here we show that Xenopus laevis Sprouty2 (XSpry2) controls the duration of ERK (show MAPK1 ELISA Kits) activity and thereby contributes to the establishment of dorsoventral patterning during mesoderm formation.
Arg119Trp variant in the SPRY2 gene was identified as the probable IgA nephropathy-causing mutation. This variant is responsible for inhibition of the MAPK (show MAPK1 ELISA Kits)/ERK1/2 (show MAPK1/3 ELISA Kits) pathway.
SPRY2, counter to its roles in other cancer settings, promotes glioma cell and tumor growth and cellular resistance to targeted inhibitors of oncogenic RTKs
Data show that proto-oncogene (show RAB1A ELISA Kits) protein B (show LEPREL2 ELISA Kits)-raf (BRAF (show BRAF ELISA Kits)) inhibition induces c-Jun N-terminal kinase (c-JUN) expression and c-JUN (show JUN ELISA Kits) abundance and activation by down-regulating SPRY2/4 protein expression.
Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer
The purpose of this study was to determine whether SPRY2 might have antiinflammatory effects on rheumatoid arthritis fibroblast-like synoviocytes.
miR21 may represent a negative regulator involved in the downregulation of SPRY2 in MM.
No association between SPRY2, single-nucleotide polymorphisms, and nonsyndromic cleft lip with or without cleft palate risk were observed in this cohort of patients.
A decrease in SPRY2 and RECK (show RECK ELISA Kits) expression by nickel-induced miR (show MLXIP ELISA Kits)-21 may promote invasiveness in lung cancer cells.
Sprouty 2 protein, but not Sprouty 4, is an independent prognostic biomarker for human epithelial ovarian cancer.
Results suggest a link between placental SPRY2 mRNA levels and placental growth, which may be modulated by maternal metabolic status and placental inflammation.
Study revealed that suppression of Spry2 expression induced proliferation and differentiation of osteoblastic cells upon bFGF (show FGF2 ELISA Kits) and EGF (show EGF ELISA Kits) stimulation, whereas it diminished proliferation of gingival epithelial cells.
in embryos with lower Spry2;Spry4 (show SPRY4 ELISA Kits) gene dosages, we observed a non-fusion of original R2 and M1 Shh (show SHH ELISA Kits) signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud
The data showed enhanced axon outgrowth and improved long-distance axon regeneration in sprouty2 deficient mice
Sprouty2 acts as an inhibitor of CrkL-Rap1 signaling.
we reveal that SPRY2 expression is regulated by FOXO3a (show FOXO3 ELISA Kits) and beta-catenin (show CTNNB1 ELISA Kits) nuclear activity in colon cancer
Spry1 (show SPRY1 ELISA Kits) and Spry2 coordination is required for normal development of the external genitalia in mice
We propose that Sprouty genes(Spry2 and Spry4 (show SPRY4 ELISA Kits)) were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution.
conjunctival epithelial Spry1 (show SPRY1 ELISA Kits) and Spry2 redundantly promote eyelid closure.
Findings indicate that leukemia inhibitory factor (LIF (show LIF ELISA Kits))-induced Stat3 (show STAT3 ELISA Kits) phosphorylation plays an important role in promoting the binding of phospho-Erk1/2 (show MAPK1/3 ELISA Kits) and Sprouty2, and thus inhibiting growth factor (FGF)-induced differentiation.
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
protein sprouty homolog 2
, sprouty 2