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Human Polyclonal STAM2 Primary Antibody for ELISA, WB - ABIN251316
Pandey, Fernandez, Steen, Blagoev, Nielsen, Roche, Mann, Lodish: Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. in The Journal of biological chemistry 2001
Show all 2 Pubmed References
Human Polyclonal STAM2 Primary Antibody for IHC, IHC (p) - ABIN4356186
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
The G-102A polymorphism in STAM2 is significantly associated with withers height, heart girth, cannon circumference, chest width, and hip height in Wuchuan Black cattle
SLBP (show SLBP Antibodies) is a potentially important cellular regulator of HIV-1, thereby establishing a link between histone metabolism, inflammation, and HIV-1 infection
showed that inhibiting the SLBP (show SLBP Antibodies) mRNA and protein levels were rescued by epigenetic modifiers suggesting that nickel's effects on SLBP (show SLBP Antibodies) may be mediated via epigenetic mechanisms
Cyclin F (show CCNF Antibodies)-mediated degradation of SLBP (show SLBP Antibodies) limits H2A.X (show H2AFX Antibodies) accumulation and apoptosis upon genotoxic stress in G2 cell cycle checkpoint.
CRL4(WDR23 (show DCAF11 Antibodies)) is required for efficient histone mRNA 3' end processing to produce mature histone mRNAs for translation. CRL4(WDR23 (show DCAF11 Antibodies)) binds and ubiquitylates SLBP (show SLBP Antibodies) in vitro and in vivo, and this modification activates SLBP (show SLBP Antibodies) function in histone mRNA 3' end processing without affecting its protein levels.
FEM1 proteins are ancient regulators of Stem-Loop Binding Protein (show SLBP Antibodies).
CRL4-DCAF11 (show DCAF11 Antibodies) mediates the degradation of SLBP (show SLBP Antibodies) at the end of S phase and this degradation is essential for the viability of cells.
The authors propose a structural organization where the AMSH (show STAMBP Antibodies)-SH3 binding motif interacts with the STAM2-SH3 domain (show ITSN1 Antibodies) and contributes to the correct positioning of AMSH (show STAMBP Antibodies) prior to polyubiquitin (show UBB Antibodies) chains' cleavage.
The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains
homologous domain of human Bro1 (show HMGCR Antibodies) domain-containing proteins, Alix (show PDCD6IP Antibodies) and Brox, binds CHMP4B (show CHMP4A Antibodies) but not STAM2, despite their high structural similarity
arsenic, a carcinogenic metal, decreases cellular levels of SLBP (show SLBP Antibodies) by inducing its proteasomal degradation and inhibiting SLBP (show SLBP Antibodies) transcription via epigenetic mechanisms
Stam2 is expressed in the nervous tissue, heart, digestive and endocrine system during embryo development.
These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors.
STAM (show STAM Antibodies) proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.
SH3 domains of STAM2 and Grb2 (show GRB2 Antibodies) retain the moderate characteristics of recognizing their ligand proteins like other SH3 domains for signal protein (show KLK7 Antibodies) binding
This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1.
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
, signal transducing adapter molecule 2
, signal transducing adaptor molecule 2
, signal transducing adapter molecule 2-like
, HSE1 homolog
, Hrs-binding protein
, STAM-like protein containing SH3 and ITAM domains 2
, Hrs binding protein
, hrs-binding protein
, EAST protein
, epidermal growth factor receptor-associated protein with SH3 and TAM domain
, hairpin binding protein, histone
, histone RNA hairpin-binding protein
, histone binding protein
, histone stem-loop binding protein
, histone stem-loop-binding protein
, stem-loop (histone) binding protein