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Cow (Bovine) Monoclonal SMARCAL1 Primary Antibody for IP, WB - ABIN2668353
Mesner, Sutherland, Hockensmith: DNA-dependent adenosinetriphosphatase A is the eukaryotic analogue of the bacteriophage T4 gene 44 protein: immunological identity of DNA replication-associated ATPases. in Biochemistry 1992
Show all 2 Pubmed References
Human Polyclonal SMARCAL1 Primary Antibody for IP, WB - ABIN257085
Yuan, Ghosal, Chen: The annealing helicase HARP protects stalled replication forks. in Genes & development 2009
found that SMARCAL1 was transcriptionally inhibited by E2F6 (show E2F6 Antibodies), an important cell cycle regulator (show CDKN2A Antibodies). Over-expression of E2F6 (show E2F6 Antibodies) in zebrafish embryos reduced the expression of smarcal1 mRNA and induced developmental defects similar to those in smarcal1 morphants
The main roles of SMARCAL1 in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress are reviewed.
our data reveal the critical function of the DNA replication stress response and, specifically, Smarcal1 in hematopoietic cell survival and tumor development. Our results also provide important insight into the immunodeficiency observed in individuals with mutations in SMARCAL1 by suggesting that it is an HSPC defect.
results provide the first identification, to our knowledge, of an endogenous source of replication stress that requires SMARCAL1 for resolution and define differences between members of this class of replication fork-repair enzymes.
the role of SMARCAL1 in the pathogenesis of Schimke immuno-osseous dysplasia
Mutation of predicted DNA-binding residues in the HARP (show C5orf13 Antibodies) domain dramatically reduced fork binding and regression activities of SMARCAL1 catalytic domain.
did not find evidence of defective NER (show NR1H2 Antibodies) or NHEJ; however, Smarcal1-deficient mice were hypersensitive to several genotoxic agents
SMARCAL1 annealing helicase (show DNA2 Antibodies) buffers fluctuations in gene expression and that alterations in gene expression contribute to the penetrance of SIOD.
A large number of SNF2 (show SMARCA2 Antibodies) family, DNA and ATP-dependent motor proteins are needed during transcription, DNA replication, and DNA repair to manipulate protein-DNA interactions and change DNA structure. SMARCAL1, ZRANB3, and HLTF (show HLTF Antibodies) are three related members of this family with specialized functions that maintain genome stability during DNA replication. [review]
BRG1 (show SMARCA4 Antibodies) and SMARCAL1, members of the ATP-dependent chromatin remodelling family, are shown to co-regulate the transcription of DROSHA (show DROSHA Antibodies), DGCR8 (show DGCR8 Antibodies), and DICER (show DICER1 Antibodies) in response to double-strand DNA breaks.
depletion of SMARCAL1, a SNF2 (show SMARCA2 Antibodies)-family DNA translocase that remodels stalled forks, restores replication fork stability and reduces the formation of replication stress-induced DNA breaks and chromosomal aberrations in BRCA1/2-deficient cells. In addition to SMARCAL1, other SNF2 (show SMARCA2 Antibodies)-family fork remodelers, including ZRANB3 and HLTF (show HLTF Antibodies), cause nascent DNA degradation and genomic instability
the mechanism of SMARCAL1 function in maintaining genome stability
deficiency of a SMARCAL1 ortholog altering the chromatin structure of a gene
Results provide evidence that BRG1 (show SMARCA4 Antibodies) and SMARCAL1 regulate each other. BRG1 (show SMARCA4 Antibodies) binds to the SMARCAL1 promoter, while SMARCAL1 binds to the brg1 (show SMARCA4 Antibodies) promoter. During DNA damage, the occupancy of SMARCAL1 on the brg1 (show SMARCA4 Antibodies) promoter increases coinciding with an increase in BRG1 (show SMARCA4 Antibodies) occupancy on the SMARCAL1 promoter, leading to increased brg1 (show SMARCA4 Antibodies) and SMARCAL1 transcripts respectively.
the replication stress response protein SMARCAL1 is a critical regulator of alternative lengthening of telomeres activity.
SMARCAL1 negatively regulates c-myc (show MYC Antibodies) transcription by altering the conformation of its promoter region during differentiation.
Brca2 (show BRCA2 Antibodies) and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarcal1 and Mre11 (show MRE11A Antibodies) predisposes to genome instability.
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a-like 1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
, hepA-related protein
, sucrose nonfermenting protein 2-like 1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1-like
, ATP-driven annealing helicase
, HepA-related protein
, SMARCA-like protein 1
, Sucrose nonfermenting protein 2-like 1