Browse our anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) Antibodies

Full name:
anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Antibodies (SMARCAL1)
On www.antibodies-online.com are 37 SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) Antibodies from 15 different suppliers available. Additionally we are shipping SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Kits (5) and SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Proteins (4) and many more products for this protein. A total of 49 SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 products are currently listed.
Synonyms:
6030401P21Rik, AI851716, HARP, HHARP, im:7145331, Mharp, si:ch211-239d11.1, SMARCAL1
list all antibodies Gene Name GeneID UniProt
SMARCAL1 54380 Q8BJL0
SMARCAL1 316477 B4F769
SMARCAL1 50485 Q9NZC9

Show all species

Show all synonyms

Most Popular Reactivities for anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) Antibodies

Select your species and application

anti-Mouse (Murine) Antibodies:

anti-Rat (Rattus) Antibodies:

anti-Human Antibodies:

All available anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Antibodies

Go to our pre-filtered search.

Top referenced anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Antibodies

  1. Cow (Bovine) Monoclonal SMARCAL1 Primary Antibody for IP, WB - ABIN2668353 : Mesner, Sutherland, Hockensmith: DNA-dependent adenosinetriphosphatase A is the eukaryotic analogue of the bacteriophage T4 gene 44 protein: immunological identity of DNA replication-associated ATPases. in Biochemistry 1992 (PubMed)
    Show all 2 references for 2668353

  2. Cow (Bovine) Polyclonal SMARCAL1 Primary Antibody for WB - ABIN2775719 : Clewing, Fryssira, Goodman, Smithson, Sloan, Lou, Huang, Choi, Lücke, Alpay, André, Asakura, Biebuyck-Gouge, Bogdanovic, Bonneau, Cancrini, Cochat, Cockfield, Collard, Cordeiro, Cormier-Daire, Cransberg, Cutka, Deschenes, Ehrich, Fründ, Georgaki, Guillen-: Schimke immunoosseous dysplasia: suggestions of genetic diversity. in Human mutation 2007 (PubMed)

  3. Human Polyclonal SMARCAL1 Primary Antibody for IHC (p), ELISA - ABIN214381 : Patel, Rowe, Winters, Ohls: Elevated erythropoietin mRNA and protein concentrations in the developing human eye. in Pediatric research 2008 (PubMed)

  4. Human Polyclonal SMARCAL1 Primary Antibody for IP, WB - ABIN257085 : Yuan, Ghosal, Chen: The annealing helicase HARP protects stalled replication forks. in Genes & development 2009 (PubMed)

More Antibodies against SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 Interaction Partners

Zebrafish SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) interaction partners

  1. found that SMARCAL1 was transcriptionally inhibited by E2F6 (show E2F6 Antibodies), an important cell cycle regulator (show CDKN2A Antibodies). Over-expression of E2F6 (show E2F6 Antibodies) in zebrafish embryos reduced the expression of smarcal1 mRNA and induced developmental defects similar to those in smarcal1 morphants

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) interaction partners

  1. our data reveal the critical function of the DNA replication stress response and, specifically, Smarcal1 in hematopoietic cell survival and tumor development. Our results also provide important insight into the immunodeficiency observed in individuals with mutations in SMARCAL1 by suggesting that it is an HSPC defect.

  2. results provide the first identification, to our knowledge, of an endogenous source of replication stress that requires SMARCAL1 for resolution and define differences between members of this class of replication fork-repair enzymes.

  3. the role of SMARCAL1 in the pathogenesis of Schimke immuno-osseous dysplasia

  4. Mutation of predicted DNA-binding residues in the HARP (show C5orf13 Antibodies) domain dramatically reduced fork binding and regression activities of SMARCAL1 catalytic domain.

  5. did not find evidence of defective NER (show NR1H2 Antibodies) or NHEJ; however, Smarcal1-deficient mice were hypersensitive to several genotoxic agents

  6. SMARCAL1 annealing helicase (show DNA2 Antibodies) buffers fluctuations in gene expression and that alterations in gene expression contribute to the penetrance of SIOD.

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) interaction partners

  1. our data reveal the critical function of the DNA replication stress response and, specifically, Smarcal1 in hematopoietic cell survival and tumor development. Our results also provide important insight into the immunodeficiency observed in individuals with mutations in SMARCAL1 by suggesting that it is an HSPC defect.

  2. the mechanism of SMARCAL1 function in maintaining genome stability

  3. deficiency of a SMARCAL1 ortholog altering the chromatin structure of a gene

  4. Results provide evidence that BRG1 (show SMARCA4 Antibodies) and SMARCAL1 regulate each other. BRG1 (show SMARCA4 Antibodies) binds to the SMARCAL1 promoter, while SMARCAL1 binds to the brg1 (show SMARCA4 Antibodies) promoter. During DNA damage, the occupancy of SMARCAL1 on the brg1 (show SMARCA4 Antibodies) promoter increases coinciding with an increase in BRG1 (show SMARCA4 Antibodies) occupancy on the SMARCAL1 promoter, leading to increased brg1 (show SMARCA4 Antibodies) and SMARCAL1 transcripts respectively.

  5. the replication stress response protein SMARCAL1 is a critical regulator of alternative lengthening of telomeres activity.

  6. SMARCAL1 negatively regulates c-myc (show MYC Antibodies) transcription by altering the conformation of its promoter region during differentiation.

  7. Mutations in human SMARCAL1 that result in loss in ATPase (show DNAH8 Antibodies) activity lead to increased replication stress and therefore possibly manifestation of Schimke immuno-osseous dysplasia.

  8. results provide the first identification, to our knowledge, of an endogenous source of replication stress that requires SMARCAL1 for resolution and define differences between members of this class of replication fork-repair enzymes.

  9. The results suggest that Smarcal1 enhances nonhomologous end-joining repair, presumably by interacting with RPA at unwound single-strand sequences and then facilitating annealing at double-strand-break ends.

  10. the role of SMARCAL1 in the pathogenesis of Schimke immuno-osseous dysplasia

Xenopus laevis SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) interaction partners

  1. Brca2 (show BRCA2 Antibodies) and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarcal1 and Mre11 (show MRE11A Antibodies) predisposes to genome instability.

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency.

Alternative names and synonyms associated with SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1)

  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (SMARCAL1) antibody
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (smarcal1) antibody
  • SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (Smarcal1) antibody
  • Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (Smarcal1) antibody
  • 6030401P21Rik antibody
  • AI851716 antibody
  • HARP antibody
  • HHARP antibody
  • im:7145331 antibody
  • Mharp antibody
  • si:ch211-239d11.1 antibody
  • SMARCAL1 antibody

Protein level used designations for SMARCAL1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a-like 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 , hepA-related protein , sucrose nonfermenting protein 2-like 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1-like , ATP-driven annealing helicase , HepA-related protein , SMARCA-like protein 1 , Sucrose nonfermenting protein 2-like 1

GENE ID SPECIES
396031 Gallus gallus
459930 Pan troglodytes
560412 Danio rerio
695741 Macaca mulatta
780385 Xenopus (Silurana) tropicalis
100013505 Monodelphis domestica
100050615 Equus caballus
100348145 Oryctolagus cuniculus
100411539 Callithrix jacchus
100454019 Pongo abelii
100471163 Ailuropoda melanoleuca
100606153 Nomascus leucogenys
100620418 Sus scrofa
54380 Mus musculus
316477 Rattus norvegicus
50485 Homo sapiens
478903 Canis lupus familiaris
338072 Bos taurus
734728 Xenopus laevis
Selected quality suppliers for anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1) Antibodies
Did you look for something else?