C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 237-399) antibody
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- Target See all C-Type Lectin Domain Family 4, Member M (CLEC4M) Antibodies
- C-Type Lectin Domain Family 4, Member M (CLEC4M)
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Binding Specificity
- AA 237-399
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- Un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Neutralization (Neut)
- Purification
- purified
- Immunogen
- Purified recombinant fragment of human CD299 (AA: extra 237-399) expressed in E. coli.
- Clone
- 8A1B3
- Isotype
- IgG1
- Top Product
- Discover our top product CLEC4M Primary Antibody
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anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 242-399) antibody
CLEC4M Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 271-320) antibodyCLEC4M Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 238-382) antibodyCLEC4M Reactivity: Human WB, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) antibodyCLEC4M Reactivity: Human IHC, FACS Host: Rabbit Chimeric 16E7 unconjugated Recombinant Antibody
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 51-100) antibodyCLEC4M Reactivity: Human, Monkey WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 285-394) antibodyCLEC4M Reactivity: Human WB, ELISA Host: Mouse Monoclonal 2G1 unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (N-Term) antibodyCLEC4M Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 285-394) antibodyCLEC4M Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 143-192) antibodyCLEC4M Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (N-Term) antibodyCLEC4M Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400, ICC: N/A, IHC: N/A
- Restrictions
- For Research Use only
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- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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- Target
- C-Type Lectin Domain Family 4, Member M (CLEC4M)
- Alternative Name
- CD299 (CLEC4M Products)
- Synonyms
- CD209L antibody, CD299 antibody, DC-SIGN2 antibody, DC-SIGNR antibody, DCSIGNR antibody, HP10347 antibody, L-SIGN antibody, LSIGN antibody, CD209B antibody, C-type lectin domain family 4 member M antibody, CLEC4M antibody
- Background
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Description: This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835, often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
Aliases: CLEC4M, LSIGN, CD209L, L-SIGN, DCSIGNR, HP10347, DC-SIGN2, DC-SIGNR
- Molecular Weight
- 45.4 kDa
- Gene ID
- 10332
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