FANCM antibody (Internal Region)
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- Target See all FANCM Antibodies
- FANCM (Fanconi Anemia Complementation Group M (FANCM))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FANCM antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificity
- FANCM Antibody detects endogenous levels of total FANCM.
- Predicted Reactivity
- Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human FANCM, corresponding to a region within the internal amino acids.
- Isotype
- IgG
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anti-Fanconi Anemia Complementation Group M (FANCM) (AA 1-669) antibody
FANCM Reactivity: Human WB, IF Host: Mouse Polyclonal unconjugated
anti-Fanconi Anemia Complementation Group M (FANCM) (AA 1752-1783) antibodyFANCM Reactivity: Human WB Host: Rabbit Polyclonal RB54125 unconjugated
anti-Fanconi Anemia Complementation Group M (FANCM) antibodyFANCM Reactivity: Human IF Host: Rabbit Polyclonal unconjugated
anti-Fanconi Anemia Complementation Group M (FANCM) (AA 390-660) antibodyFANCM Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- FANCM (Fanconi Anemia Complementation Group M (FANCM))
- Alternative Name
- FANCM (FANCM Products)
- Synonyms
- FAAP250 antibody, KIAA1596 antibody, AI427100 antibody, C730036B14Rik antibody, D12Ertd364e antibody, Fanconi anemia complementation group M antibody, hypothetical protein antibody, Fanconi anemia, complementation group M antibody, FANCM antibody, PGTG_17854 antibody, Fancm antibody
- Background
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Description: DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434).
Gene: FANCM
- Molecular Weight
- 232 kDa
- Gene ID
- 57697
- UniProt
- Q8IYD8
- Pathways
- DNA Damage Repair
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