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Claudin 16 antibody (N-Term)

CLDN16 Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB30098 unconjugated
Catalog No. ABIN654394
  • Target See all Claudin 16 (CLDN16) Antibodies
    Claudin 16 (CLDN16)
    Binding Specificity
    • 15
    • 7
    • 7
    • 7
    • 3
    • 2
    • 1
    AA 6-33, N-Term
    Reactivity
    • 37
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 35
    • 2
    Rabbit
    Clonality
    • 36
    • 1
    Polyclonal
    Conjugate
    • 13
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Claudin 16 antibody is un-conjugated
    Application
    • 20
    • 18
    • 14
    • 13
    • 13
    • 13
    • 5
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This CLDN16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-33 amino acids from the N-terminal region of human CLDN16.
    Clone
    RB30098
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    Claudin 16 (CLDN16)
    Alternative Name
    CLDN16 (CLDN16 Products)
    Synonyms
    CLDN16 antibody, HOMG3 antibody, PCLN1 antibody, claudin-16 antibody, Pcln1 antibody, claudin 16 antibody, CLDN16 antibody, Cldn16 antibody
    Background
    Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28.
    Molecular Weight
    33836
    Gene ID
    10686
    NCBI Accession
    NP_006571
    UniProt
    Q9Y5I7
    Pathways
    Hepatitis C
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