EGLN1 antibody
-
- Target See all EGLN1 Antibodies
- EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))
-
Reactivity
- Human, Mouse, Rat
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This EGLN1 antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human EGLN1
- Isotype
- IgG
-
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 1-426) antibody
KO Validated EGLN1 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) antibodyEGLN1 Reactivity: Human, Mouse, Rat IHC Host: Rabbit Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 300-400) antibodyEGLN1 Reactivity: Mouse WB, IHC, IF, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) antibodyEGLN1 Reactivity: Human WB, IHC, FACS Host: Rabbit Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 301-426) antibodyEGLN1 Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 42-140) antibodyEGLN1 Reactivity: Human, Mouse WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (Internal Region) antibodyEGLN1 Reactivity: Human, Mouse, Rat WB, IHC, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 272-355) antibodyEGLN1 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) (AA 350-426) antibodyEGLN1 Reactivity: Human WB, IHC, IP Host: Rabbit Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1) antibodyEGLN1 Reactivity: Human, Mouse, Rat WB, IHC, IF, IC Host: Rabbit Polyclonal unconjugated
-
- Application Notes
- Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid freeze / thaw cycles
- Storage
- -20 °C/-80 °C
-
- Target
- EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))
- Alternative Name
- EGLN1 (EGLN1 Products)
- Background
-
PHD1 (Egln2), PHD-2 (Egln1), and PHD3 (Egln3) are members of the Egln family of proline hydroxylases. They function as oxygen sensors that catalyze the hydroxylation of HIF on prolines 564 and 402, initiating the first step of HIF degradation through the VHL/ubiquitin pathway. PHD1 is highly expressed in a wide array of tissues whereas PHD2 and PHD3 are expressed mainly in heart and skeletal muscle. The mRNA levels of PHD are upregulated by HIF through the hypoxia-response element under low oxygen conditions. These three enzymes also exhibit different peptide specificity target proteins, PHD1 and PHD2 can hydroxylate both proline 402 and proline 564, but PHD3 can only hydroxylate proline 564. In addition to HIF, PHD enzymes have also has been shown to catalyze the hydroxylation of RNA polymerase subunits and myogenin.
Synonyms: EGLN1, C1orf12, DKFZp761F179, ECYT3, HIFPH2, HPH2, PHD2, SM-20, SM20, ZMYND6 - Gene ID
- 54583
- UniProt
- Q9GZT9
- Pathways
- cAMP Metabolic Process, Warburg Effect
-
