CHRNA7 antibody (AA 52-259)
(3 references)-
- Target See all CHRNA7 Antibodies
- CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))
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Binding Specificity
- AA 52-259
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CHRNA7 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Neutralization (Neut)
- Purification
- purified
- Immunogen
- Purified recombinant fragment of human CHRNA7 (AA: extra 52-259) expressed in E. coli.
- Clone
- 7F10G1
- Isotype
- IgG1
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anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (AA 441-502) antibody
CHRNA7 Reactivity: Human, Rat, Mouse WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (AA 52-259) antibodyCHRNA7 Reactivity: Human, Rat WB, ELISA, IHC, ICC, FACS, Neut Host: Mouse Monoclonal 7F10F1 unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (AA 23-230) antibodyCHRNA7 Reactivity: Human WB, IHC, ICC, IP Host: Rabbit Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) antibodyCHRNA7 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (AA 23-230) antibodyCHRNA7 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (N-Term) antibodyCHRNA7 Reactivity: Human, Rat, Mouse, Cow WB Host: Rabbit Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (AA 31-42), (Extracellular), (N-Term) antibodyCHRNA7 Reactivity: Human, Rat, Mouse WB, IHC, ICC, FACS, IF, LCI Host: Rabbit Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (Internal Region) antibodyVerified CHRNA7 Reactivity: Human, Rat ELISA, IHC Host: Goat Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) antibodyCHRNA7 Reactivity: Human, Rat, Mouse IHC Host: Rabbit Polyclonal unconjugated
anti-Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7) (C-Term) antibodyCHRNA7 Reactivity: Human, Rat, Mouse, Cow, Dog, Horse, Rabbit, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: 1:200 - 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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: "Extracellular Vesicles Derived from Metastatic Melanoma Cells Transfer α7-nAChR mRNA, Thus Increasing the Surface Expression of the Receptor and Stimulating the Growth of Normal Keratinocytes." in: Acta naturae, Vol. 14, Issue 3, pp. 95-99, (2022) (PubMed).
: "SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer." in: Frontiers in cell and developmental biology, Vol. 9, pp. 739391, (2021) (PubMed).
: "Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain." in: Frontiers in cell and developmental biology, Vol. 9, pp. 662227, (2021) (PubMed).
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: "Extracellular Vesicles Derived from Metastatic Melanoma Cells Transfer α7-nAChR mRNA, Thus Increasing the Surface Expression of the Receptor and Stimulating the Growth of Normal Keratinocytes." in: Acta naturae, Vol. 14, Issue 3, pp. 95-99, (2022) (PubMed).
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- Target
- CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))
- Alternative Name
- CHRNA7 (CHRNA7 Products)
- Synonyms
- CHRNA7-2 antibody, NACHRA7 antibody, dZ70B1.1 antibody, Acra7 antibody, alpha7 antibody, BTX antibody, NARAD antibody, nAChRa7 antibody, CHRNA7 antibody, cholinergic receptor nicotinic alpha 7 subunit antibody, neuronal acetylcholine receptor subunit alpha-7 antibody, cholinergic receptor, nicotinic, alpha 7 (neuronal) antibody, cholinergic receptor, nicotinic, alpha polypeptide 7 antibody, cholinergic receptor, nicotinic, alpha 7 antibody, CHRNA7 antibody, LOC100374356 antibody, chrna7 antibody, Chrna7 antibody, LOC100060521 antibody
- Background
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Description: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.
Aliases: NACHRA7, CHRNA7-2
- Molecular Weight
- 56.4 kDa
- Gene ID
- 1139
- HGNC
- 1139
- Pathways
- Synaptic Membrane
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