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ARAP1 antibody (AA 1190-1450)

ARAP1 Reactivity: Human WB, IP, ICC Host: Mouse Monoclonal ARAP1-2 unconjugated
Catalog No. ABIN302078
  • Target See all ARAP1 Antibodies
    ARAP1 (ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1))
    Binding Specificity
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 1190-1450
    Reactivity
    • 24
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 21
    • 2
    • 1
    Mouse
    Clonality
    • 22
    • 2
    Monoclonal
    Conjugate
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ARAP1 antibody is un-conjugated
    Application
    • 11
    • 7
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Specificity
    The antibody ARAP1-2 reacts with C-terminal part of ARAP1 (intracellular epitope), a 160 kDa adaptor protein.
    Cross-Reactivity (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1
    Clone
    ARAP1-2
    Isotype
    IgG1
  • Application Notes
    Western blotting: Recommended dilution: 2 μg/mL
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Símová, Klíma, Cermak, Sourková, Andera: "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane." in: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 3, pp. 423-36, (2008) (PubMed).

  • Target
    ARAP1 (ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1))
    Alternative Name
    ARAP1 (ARAP1 Products)
    Synonyms
    CENTD2 antibody, ARAP1 antibody, Ci-ArfGAP-8 antibody, 2410002L19Rik antibody, Centd2 antibody, mKIAA0782 antibody, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 antibody, centaurin, delta 2 antibody, ARAP1 antibody, centd2 antibody, Arap1 antibody
    Background
    ArfGAP with RhoGAP domain, ankyrin repeat and PH d,ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.,CED2, CENTD2
    Gene ID
    116985
    UniProt
    Q96P48
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