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ATF2 antibody (pThr51, pThr69)

ATF2 Reactivity: Human, Mouse, Rat WB, IHC, ELISA, IP, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6256594
  • Target See all ATF2 Antibodies
    ATF2 (Activating Transcription Factor 2 (ATF2))
    Binding Specificity
    • 49
    • 35
    • 26
    • 26
    • 24
    • 23
    • 23
    • 23
    • 15
    • 15
    • 14
    • 14
    • 12
    • 10
    • 9
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr51, pThr69
    Reactivity
    • 294
    • 228
    • 205
    • 16
    • 12
    • 11
    • 8
    • 7
    • 7
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 326
    • 12
    • 2
    • 1
    Rabbit
    Clonality
    • 312
    • 29
    Polyclonal
    Conjugate
    • 153
    • 20
    • 16
    • 16
    • 16
    • 15
    • 15
    • 15
    • 13
    • 12
    • 9
    • 8
    • 8
    • 8
    • 8
    • 5
    • 4
    This ATF2 antibody is un-conjugated
    Application
    • 240
    • 117
    • 112
    • 111
    • 75
    • 61
    • 58
    • 34
    • 33
    • 22
    • 14
    • 10
    • 6
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    Phospho-ATF2 (Thr69/Thr51) Antibody detects endogenous levels of ATF2 only when phosphorylated at Threonine 69 or 51.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human ATF2 around the phosphorylation site of Thr69 or 51.
    Isotype
    IgG
    Top Product
    Discover our top product ATF2 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IP, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    ATF2 (Activating Transcription Factor 2 (ATF2))
    Alternative Name
    ATF2 (ATF2 Products)
    Synonyms
    CRE-BP1 antibody, CREB2 antibody, HB16 antibody, TREB7 antibody, CG12850 antibody, CG3749 antibody, dATF-2 antibody, DmelCG30420 antibody, CG30420 antibody, CHN1 antibody, Atf-2 antibody, CRE-BP antibody, Creb2 antibody, D130078H02Rik antibody, D18875 antibody, Tg(Gzma-Klra1)7Wum antibody, mXBP antibody, atf2-A antibody, atf2l antibody, activating transcription factor 2 antibody, Activating transcription factor-2 antibody, activating transcription factor 2 S homeolog antibody, ATF2 antibody, Atf-2 antibody, Atf2 antibody, atf2.S antibody, atf2 antibody
    Background

    Description: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

    Gene: ATF2

    Molecular Weight
    52kDa
    Gene ID
    1386
    UniProt
    P15336
    Pathways
    MAPK Signaling, RTK Signaling, Thyroid Hormone Synthesis, Activation of Innate immune Response, Chromatin Binding, Myometrial Relaxation and Contraction, Synaptic Membrane, Tube Formation, Toll-Like Receptors Cascades
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