SPPL3 antibody (AA 213-263)
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- Target See all SPPL3 Antibodies
- SPPL3 (Signal Peptide Peptidase 3 (SPPL3))
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Binding Specificity
- AA 213-263
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SPPL3 antibody is un-conjugated
- Application
- ELISA, Western Blotting (WB), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Signal peptide peptidase-like 3 protein (213-263AA)
- Isotype
- IgG
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anti-Signal Peptide Peptidase 3 (SPPL3) (AA 50-81), (N-Term) antibody
SPPL3 Reactivity: Human WB Host: Rabbit Polyclonal RB2276 unconjugated
anti-Signal Peptide Peptidase 3 (SPPL3) (AA 215-264) antibodySPPL3 Reactivity: Human, Monkey, Mouse, Pig, Rabbit, Chicken, Rat, Cow, Xenopus laevis, Guinea Pig, Zebrafish (Danio rerio), Horse WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Recommended dilution: WB:1:200-1:2000, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- SPPL3 (Signal Peptide Peptidase 3 (SPPL3))
- Alternative Name
- SPPL3 (SPPL3 Products)
- Synonyms
- CG17370 antibody, CG5901 antibody, Dmel\\CG17370 antibody, SPPL3 antibody, Sppl antibody, sppL antibody, RGD1562826 antibody, Sppl3-ps1 antibody, MGC52975 antibody, sppl3 antibody, MGC75937 antibody, fb94d08 antibody, wu:fb94d08 antibody, zgc:114093 antibody, 4833416I09Rik antibody, Psl4 antibody, Usmg3 antibody, IMP2 antibody, MDHV1887 antibody, PRO4332 antibody, PSH1 antibody, PSL4 antibody, Signal peptide peptidase-like antibody, signal peptide peptidase like 3 antibody, signal peptide peptidase like 3 L homeolog antibody, signal peptide peptidase 3 antibody, Intramembrane protease 2 antibody, SppL antibody, Sppl3 antibody, sppl3.L antibody, sppl3 antibody, SPPL3 antibody, imp-2 antibody
- Background
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Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).
Aliases: SPPL3 antibody, IMP2 antibody, PSL4 antibody, Signal peptide peptidase-like 3 antibody, SPP-like 3 antibody, EC 3.4.23.- antibody, Intramembrane protease 2 antibody, IMP-2 antibody, Presenilin homologous protein 1 antibody, PSH1 antibody, Presenilin-like protein 4 antibody
- UniProt
- Q8TCT6
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