BRCA1 antibody (pSer1423)
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- Target See all BRCA1 Antibodies
- BRCA1 (Breast Cancer 1 (BRCA1))
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Binding Specificity
- pSer1423
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This BRCA1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Characteristics
- Phosphorylated antibody
- Purification
- Affinity purification
- Immunogen
- A synthetic phosphorylated peptide around S1423 of human BRCA1 (NP_009225.1).
- Isotype
- IgG
- Top Product
- Discover our top product BRCA1 Primary Antibody
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anti-Breast Cancer 1 (BRCA1) (AA 19-83) antibody
BRCA1 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 229-335) antibodyBRCA1 Reactivity: Human WB, IHC, ELISA Host: Mouse Monoclonal 6C6D2 unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 400-699) antibodyBRCA1 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 1661-1863) antibodyBRCA1 Reactivity: Human, Rat, Mouse WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (Ser184) antibodyBRCA1 Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (Ser184), (Ser186) antibodyBRCA1 Reactivity: Human, Rat WB, IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) antibodyBRCA1 Reactivity: Human, Rat WB, ELISA, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 445-620) antibodyBRCA1 Reactivity: Human IHC, ISt, StM Host: Mouse Monoclonal BRCA1-1398 unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 400-699) antibodyBRCA1 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Breast Cancer 1 (BRCA1) (AA 1314-1864) antibodyBRCA1 Reactivity: Human WB, IF, IP Host: Mouse Monoclonal MU unconjugated
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- Application Notes
- WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- BRCA1 (Breast Cancer 1 (BRCA1))
- Alternative Name
- BRCA1 (BRCA1 Products)
- Synonyms
- BRCAI antibody, BRCC1 antibody, BROVCA1 antibody, IRIS antibody, PNCA4 antibody, PPP1R53 antibody, PSCP antibody, RNF53 antibody, iris antibody, pscp antibody, brcai antibody, brcc1 antibody, rnf53 antibody, brca1 antibody, BRCA1 antibody, LOC100224649 antibody, BRCA1, DNA repair associated antibody, breast cancer 1 antibody, breast cancer 1, early onset antibody, breast cancer 1 L homeolog antibody, BRCA1 antibody, brca1 antibody, LOC755086 antibody, Brca1 antibody, brca1.L antibody
- Background
- This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
- Molecular Weight
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Observed_MW: 270 kDa
Calculated_MW: 7 kDa/78-85 kDa/202-210 kDa
- Gene ID
- 672
- UniProt
- P38398
- Pathways
- Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
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