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CXCR4 antibody (AA 201-294)

CXCR4 Reactivity: Human, Mouse, Rat, Rabbit WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN730888
  • Target See all CXCR4 Antibodies
    CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
    Binding Specificity
    • 24
    • 15
    • 14
    • 12
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-294
    Reactivity
    • 149
    • 94
    • 75
    • 21
    • 13
    • 12
    • 11
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Rabbit
    Host
    • 126
    • 21
    • 12
    • 6
    • 1
    Rabbit
    Clonality
    • 137
    • 29
    Polyclonal
    Conjugate
    • 97
    • 8
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CXCR4 antibody is un-conjugated
    Application
    • 119
    • 56
    • 45
    • 35
    • 31
    • 25
    • 24
    • 24
    • 19
    • 12
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human, Mouse, Rabbit, Rat
    Predicted Reactivity
    Cow
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CXCR4
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Sha, Yang, Lv: "MGF E peptide improves anterior cruciate ligament repair by inhibiting hypoxia-induced cell apoptosis and accelerating angiogenesis." in: Journal of cellular physiology, Vol. 234, Issue 6, pp. 8846-8861, (2019) (PubMed).

    Zhuang, Li, Huang, Lei, Yan, Li, Sidhu, Cheng, Yan, Miao, Zhao, Hua: "Reelin regulates male mouse reproductive capacity via the sertoli cells." in: Journal of cellular biochemistry, (2018) (PubMed).

    Ochi, Chen, Schulte, Leng, Moeckel, Piecychna, Averdunk, Stoppe, Bucala, Moeckel: "MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms." in: American journal of physiology. Renal physiology, Vol. 313, Issue 3, pp. F767-F780, (2017) (PubMed).

    Aerbajinai, Liu, Zhu, Kumkhaek, Chin, Rodgers: "Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin." in: The Journal of biological chemistry, Vol. 291, Issue 16, pp. 8549-64, (2016) (PubMed).

    Wang, Chen, Tang, Jiang, Ji: "AMD3100 Attenuates Matrix Metalloprotease-3 and -9 Expressions and Prevents Cartilage Degradation in a Monosodium Iodo-Acetate-Induced Rat Model of Temporomandibular Osteoarthritis." in: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Vol. 74, Issue 5, pp. 927.e1-927.e13, (2016) (PubMed).

    Mori, Matsubara, Matsubara, Uchikura, Hashimoto, Fujioka, Matsumoto: "Stromal Cell-Derived Factor-1? Plays a Crucial Role Based on Neuroprotective Role in Neonatal Brain Injury in Rats." in: International journal of molecular sciences, Vol. 16, Issue 8, pp. 18018-32, (2015) (PubMed).

    Mu, Li, Wu, Zheng, Zhai, Li, Song, Wang, Zhu, Li, Hua: "PLZF-Induced Upregulation of CXCR4 Promotes Dairy Goat Male Germline Stem Cell Proliferation by Targeting Mir146a." in: Journal of cellular biochemistry, (2015) (PubMed).

    Zhou, Yang, Xin, Zhang, Hu, Zhou, Chen, Chen et al.: "Exendin-4 enhances the migration of adipose-derived stem cells to neonatal rat ventricular cardiomyocyte-derived conditioned medium via the phosphoinositide 3-kinase/Akt-stromal cell-derived ..." in: Molecular medicine reports, (2015) (PubMed).

    Zhou, Li, Shi, Xin, Yang, Zhou, Hu, Tian, Wang, Chen: "Effects of Exendin-4 on bone marrow mesenchymal stem cell proliferation, migration and apoptosis in vitro." in: Scientific reports, Vol. 5, pp. 12898, (2015) (PubMed).

    Pei, Zeng, Han, Liao, Zhou, Li, Zhang, Liu, Zhang, Liu, Yao, Xu: "Renal interstitial infiltration and tertiary lymphoid organ neogenesis in IgA nephropathy." in: Clinical journal of the American Society of Nephrology : CJASN, Vol. 9, Issue 2, pp. 255-64, (2014) (PubMed).

    Wu, Liu, Yan, He, Ye, Cheng, Zhu, Wu, Wang, Kong, Xu, Lobie, Zhu, Wu: "B-cell lymphoma 6 protein stimulates oncogenicity of human breast cancer cells." in: BMC cancer, Vol. 14, pp. 418, (2014) (PubMed).

    Li, Shen, Miao, Luan, Sun, Qiu: "Co-expression of uPAR and CXCR4 promotes tumor growth and metastasis in small cell lung cancer." in: International journal of clinical and experimental pathology, Vol. 7, Issue 7, pp. 3771-80, (2014) (PubMed).

    Lu, Qi, Bo, Liu, Wang, Li: "Expression of CD26 and CXCR4 in prostate carcinoma and its relationship with clinical parameters." in: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, Vol. 18, Issue 8, pp. 647-52, (2013) (PubMed).

    Liu, Patzak, Zhang: "CXCR4-overexpressing bone marrow-derived mesenchymal stem cells improve repair of acute kidney injury." in: American journal of physiology. Renal physiology, Vol. 305, Issue 7, pp. F1064-73, (2013) (PubMed).

    Zhuo, Jia, Song, Lu, Ding, Wang, Song, Fu, Luo: "The CXCL12-CXCR4 chemokine pathway: a novel axis regulates lymphangiogenesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 19, pp. 5387-98, (2012) (PubMed).

    Fontana, Vogt, Hohenstein, Vettermann, Doroshenko, Lammer, Yard, Hoeger: "Impact of Steroids on the Inflammatory Response after Ischemic Acute Kidney Injury in Rats." in: Indian journal of nephrology, Vol. 27, Issue 5, pp. 365-371 (PubMed).

  • Target
    CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
    Alternative Name
    CXCR4 (CXCR4 Products)
    Synonyms
    CD184 antibody, D2S201E antibody, FB22 antibody, HM89 antibody, HSY3RR antibody, LAP3 antibody, LCR1 antibody, LESTR antibody, NPY3R antibody, NPYR antibody, NPYRL antibody, NPYY3R antibody, WHIM antibody, Cmkar4 antibody, PB-CKR antibody, PBSF/SDF-1 antibody, Sdf1r antibody, CXC-R4-B antibody, CXCR-4-B antibody, cd184 antibody, cxcr4 antibody, fb22 antibody, hm89 antibody, hsy3rr antibody, lap3 antibody, lcr1 antibody, lestr antibody, npy3r antibody, npyr antibody, npyrl antibody, npyy3r antibody, xcxcr4 antibody, CXC-R4 antibody, CXCR-4 antibody, d2s201e antibody, whim antibody, CXC-R4-A antibody, CXCR-4-A antibody, xCXCR4 antibody, CXCR4 antibody, cb403 antibody, zgc:109863 antibody, cb824 antibody, C-X-C motif chemokine receptor 4 antibody, chemokine (C-X-C motif) receptor 4 antibody, C-X-C motif chemokine receptor 4 S homeolog antibody, C-X-C chemokine receptor type 4 antibody, C-X-C motif chemokine receptor 4 L homeolog antibody, chemokine (C-X-C motif), receptor 4b antibody, chemokine (C-X-C motif) receptor 4a antibody, CXCR4 antibody, Cxcr4 antibody, cxcr4.S antibody, cxcr4 antibody, LOC100049444 antibody, cxcr4.L antibody, cxcr4b antibody, cxcr4a antibody
    Background

    Synonyms: C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, Leukocyte-derived seven transmembrane domain receptor, LESTR, Lipopolysaccharide-associated protein 3, LAP-3, LPS-associated protein 3, NPYRL, Stromal cell-derived factor 1 receptor, SDF-1 receptor, CD184, CXCR4

    Background: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin, leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

    Gene ID
    7852
    Pathways
    Regulation of Cell Size, CXCR4-mediated Signaling Events
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