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UHMK1 antibody (N-Term)

UHMK1 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB3367 unconjugated
Catalog No. ABIN392641
  • Target See all UHMK1 Antibodies
    UHMK1 (U2AF Homology Motif (UHM) Kinase 1 (UHMK1))
    Binding Specificity
    • 24
    • 15
    • 12
    • 6
    • 3
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reactivity
    • 35
    • 30
    • 26
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 56
    • 4
    • 1
    Rabbit
    Clonality
    • 58
    • 3
    Polyclonal
    Conjugate
    • 16
    • 7
    • 7
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This UHMK1 antibody is un-conjugated
    Application
    • 48
    • 34
    • 17
    • 13
    • 13
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    Rat
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This KIST (KIS) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KIST (KIS).
    Clone
    RB3367
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Chen, Xie, Gu, Cai, Wang, Xie, Dong, He, Zhong, Lin, Huang: "Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation." in: Scientific reports, Vol. 5, pp. 8293, (2015) (PubMed).

    Lee, Kay: "PI 3-kinase/Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2." in: Investigative ophthalmology & visual science, Vol. 52, Issue 1, pp. 417-26, (2011) (PubMed).

    Nakamura, Yamashita, Yokota, Hirano, Ono, Fujie, Shibata, Niimi, Suyama, Maddali, Asai, Yamashita, Iguchi, Ohnishi: "Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity." in: Investigational new drugs, Vol. 28, Issue 4, pp. 381-91, (2010) (PubMed).

    Takemura, Nakamura, Yokota, Hirano, Ono, Shigeno, Fujisawa, Ohnishi: "Reduction of Raf kinase inhibitor protein expression by Bcr-Abl contributes to chronic myelogenous leukemia proliferation." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6585-94, (2010) (PubMed).

    Nakamura, Hirano, Okinaka, Takemura, Yokota, Ono, Shigeno, Shibata, Fujisawa, Ohnishi: "The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia." in: Carcinogenesis, Vol. 31, Issue 11, pp. 2012-21, (2010) (PubMed).

    Petrovic, Costa, Lau, Raychaudhuri, Tyner: "FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression." in: The Journal of biological chemistry, Vol. 283, Issue 1, pp. 453-60, (2007) (PubMed).

  • Target
    UHMK1 (U2AF Homology Motif (UHM) Kinase 1 (UHMK1))
    Alternative Name
    KIST (KIS) (UHMK1 Products)
    Synonyms
    UHMK1 antibody, zgc:153241 antibody, KIS antibody, KIST antibody, P-CIP2 antibody, 4732477C12Rik antibody, 4930500M09Rik antibody, AA673513 antibody, AI449218 antibody, AU021979 antibody, Kist antibody, U2AF homology motif kinase 1 antibody, U2AF homology motif (UHM) kinase 1 antibody, UHMK1 antibody, uhmk1 antibody, Uhmk1 antibody
    Background
    Upon serum stimulation, KIS, a member of the Ser/Thr protein kinase family, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. This protein, which contains 1 RRM (RNA recognition motif)domain, may be involved in trafficking and/or processing of RNA. KIS is widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.
    Molecular Weight
    46546
    Gene ID
    127933
    NCBI Accession
    NP_001171692, NP_653225, NP_787062
    UniProt
    Q8TAS1
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