CPEB1 antibody (Internal Region)
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- Target See all CPEB1 Antibodies
- CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1))
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Binding Specificity
- Internal Region
- Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CPEB1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificity
- CPEB1 Antibody detects endogenous levels of total CPEB1.
- Predicted Reactivity
- Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human CPEB1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product CPEB1 Primary Antibody
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anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (AA 1-486) antibody
CPEB1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (AA 311-561) antibodyCPEB1 Reactivity: Human WB, IHC, ICC Host: Rabbit Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (C-Term) antibodyVerified CPEB1 Reactivity: Human WB, ELISA Host: Goat Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (C-Term) antibodyCPEB1 Reactivity: Human WB, ICC, IF Host: Rabbit Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (AA 1-486) antibodyCPEB1 Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) (AA 282-561) antibodyCPEB1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1))
- Alternative Name
- CPEB1 (CPEB1 Products)
- Synonyms
- CEBP antibody, CPE-BP1 antibody, CPEB antibody, AU024112 antibody, Cpeb antibody, mCPEB antibody, CPEB1 antibody, cpeb1 antibody, ZOR-1 antibody, cepb1b antibody, fd15c06 antibody, wu:fd15c06 antibody, zorba antibody, cytoplasmic polyadenylation element binding protein 1 antibody, hypothetical protein antibody, cytoplasmic polyadenylation element binding protein 1 L homeolog antibody, cytoplasmic polyadenylation element binding protein 1b antibody, cytoplasmic polyadenylation element binding protein 1 S homeolog antibody, CPEB1 antibody, Cpeb1 antibody, cpeb1 antibody, LOAG_17395 antibody, cpeb1.L antibody, cpeb1b antibody, cpeb1.S antibody
- Background
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Description: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA, a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites, those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry (PubMed:26398195).
Gene: CPEB1
- Molecular Weight
- 63 kDa
- Gene ID
- 64506
- UniProt
- Q9BZB8
- Pathways
- Synaptic Membrane
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