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Cortactin antibody (pTyr466)

Name: Cortactin antibody (pTyr466)
SKU: ABIN6256746
Price: 390.77 USD
Availability: InStock

CTTN Reactivity: Human, Mouse, Rat WB, IHC, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated

Western blot analysis of Cortactin phosphorylation expression in COS7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

IF/ICC

ABIN6267646 at 1/200 staining human brain tissue sections by IHC-P.

IHC

Western blot analysis of Phospho-Cortactin (Tyr466) expression in various lysates

4 images

Catalog No. ABIN6256746

Datasheet as PDF

Target See all Cortactin (CTTN) Antibodies

Cortactin (CTTN)
Binding Specificity
15

12

12

7

7

7

6

6

5

4

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pTyr466
Reactivity
122

59

42

5

4

2

2

2

2

2

2

1

1

1
Human, Mouse, Rat
Host
122

6

1
Rabbit
Compatible Secondaries
Clonality
113

16
Polyclonal
Conjugate
72

8

5

5

5

5

5

5

4

4

3

3

1

1

1

1

1
This Cortactin antibody is un-conjugated
Application
94

51

50

15

15

14

13

11

9

6

4

3

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity

Phospho-Cortactin (Tyr466) Antibody detects endogenous levels of Cortactin only when phosphorylated at Tyrosine 466.

Predicted Reactivity

Rabbit,Dog,Xenopus

Purification

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen

A synthesized peptide derived from mouse Cortactin(Q60598) around the phosphorylation site of Tyr466.

Isotype

IgG

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Application Notes

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

-20 °C

Storage Comment

Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date

12 months
Target

Cortactin (CTTN)

Alternative Name

CTTN (CTTN Products)

Synonyms

EMS1 antibody, 1110020L01Rik antibody, Ems1 antibody, Cttnb antibody, CG3637 antibody, Dmel\CG3637 antibody, cortactin antibody, cttn antibody, CTTN1 antibody, P85.25 antibody, Cttn antibody, ems1 antibody, CTTN antibody, cortactin antibody, CG3637 gene product from transcript CG3637-RD antibody, cortactin S homeolog antibody, cortactin L homeolog antibody, src substrate cortactin antibody, Src substrate cortactin antibody, CTTN antibody, Cttn antibody, Cortactin antibody, cttn.S antibody, cttn.L antibody, cttn antibody, CpipJ_CPIJ006351 antibody, Bm1_57220 antibody, LOC100533277 antibody

Background

Description: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).
Gene: CTTN

Molecular Weight

85kDa

Gene ID

2017

UniProt

Q14247

Pathways

MAPK Signaling