EPS15 antibody (pTyr849)
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- Target See all EPS15 Antibodies
- EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))
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Binding Specificity
- pTyr849
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This EPS15 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- Phospho-EPS15 (Tyr849) Antibody detects endogenous levels of EPS15 only when phosphorylated at Tyrosine 849.
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human EPS15 around the phosphorylation site of Tyr849.
- Isotype
- IgG
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anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) antibody
EPS15 Reactivity: Human, Mouse ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (pTyr849) antibodyEPS15 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (pTyr849) antibodyEPS15 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (AA 840-870), (C-Term) antibodyEPS15 Reactivity: Human WB Host: Rabbit Polyclonal RB04393-04394 unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (AA 794-843) antibodyEPS15 Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Guinea Pig, Monkey, Rabbit, Bat WB Host: Rabbit Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (AA 2-88) antibodyEPS15 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (C-Term) antibodyEPS15 Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Dog, Guinea Pig, Rabbit WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))
- Alternative Name
- EPS15 (EPS15 Products)
- Synonyms
- AF-1P antibody, AF1P antibody, MLLT5 antibody, CG16932 antibody, Dmel\\CG16932 antibody, EH1 antibody, EPS-15 antibody, Eps15 antibody, anon-WO0118547.85 antibody, eps-15 antibody, eps15 antibody, i31 antibody, 2410112D09Rik antibody, RGD1307641 antibody, epidermal growth factor receptor pathway substrate 15 antibody, Epidermal growth factor receptor pathway substrate clone 15 antibody, hypothetical protein antibody, EPS15 antibody, Eps-15 antibody, eps15 antibody, Eps15 antibody, PGTG_06574 antibody
- Background
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Description: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR), internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Gene: EPS15
- Molecular Weight
- 98kDa
- Gene ID
- 2060
- UniProt
- P42566
- Pathways
- EGFR Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, EGFR Downregulation
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