MUC4 antibody (AA 1501-1613)
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- Target See all MUC4 Antibodies
- MUC4 (Mucin 4, Cell Surface Associated (MUC4))
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Binding Specificity
- AA 1501-1613
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MUC4 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Human, Mouse
- Predicted Reactivity
- Rat,Cow,Pig,Horse,Guinea Pig
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Muc4
- Isotype
- IgG
- Top Product
- Discover our top product MUC4 Primary Antibody
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anti-Mucin 4, Cell Surface Associated (MUC4) (AA 79-188) antibody
MUC4 Reactivity: Human WB, ELISA, IHC (p) Host: Mouse Monoclonal 5B12 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1730-1864) antibodyMUC4 Reactivity: Human IHC, StM Host: Mouse Monoclonal MUC4-3105 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1730-1864) antibodyMUC4 Reactivity: Human IHC, StM Host: Mouse Monoclonal MUC4-3084 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) antibodyMUC4 Reactivity: Human IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 79-188) antibodyMUC4 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 529-560), (N-Term) antibodyMUC4 Reactivity: Human WB Host: Rabbit Polyclonal RB49957 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) antibodyMUC4 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1154-1309) antibodyMUC4 Reactivity: Human WB, IHC, ICC Host: Rabbit Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (N-Term) antibodyMUC4 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1249-1444) antibodyMUC4 Reactivity: Human, Rat WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- MUC4 (Mucin 4, Cell Surface Associated (MUC4))
- Alternative Name
- Mucin 4 (MUC4 Products)
- Synonyms
- 4933405I11Rik antibody, Asgp antibody, ASGP antibody, HSA276359 antibody, MUC-4 antibody, ASGP-1 antibody, Psmc antibody, mucin 4 antibody, mucin 4, cell surface associated antibody, Muc4 antibody, MUC4 antibody
- Background
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Synonyms: ASGP, MUC-4, HSA276359, Mucin-4, Ascites sialoglycoprotein, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin, MUC4
Background: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.
- Gene ID
- 4585
- UniProt
- Q99102
- Pathways
- Regulation of Leukocyte Mediated Immunity
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