For best experience we recommend to activate Javascript in your browser.

FASL antibody (AA 196-281)

Name: FASL antibody (AA 196-281)
SKU: ABIN726410
Price: 384.62 USD
Availability: InStock

FASL Reactivity: Human, Mouse, Rat, Pig WB, FACS, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated

Effects of different p,p'-DDE concentrations on the FasL and caspase-3 and -8 mRNA in rat Sertoli cells by RT-PCR (a)-(c).

Formalin-fixed and paraffin embedded: human rectal carcinoma labeled with Anti-FasL Polyclonal Antibody, Unconjugated (ABIN726410) at 1:200, followed by conjugation to the secondary antibody and DAB staining

IHC

Formalin-fixed and paraffin embedded: rat brain tissue labeled with Anti-FasL Polyclonal Antibody, Unconjugated (ABIN726410) at 1:200, followed by conjugation to the secondary antibody and DAB staining

IHC

Formalin-fixed and paraffin embedded: human rectal carcinoma labeled with Anti-FasL Polyclonal Antibody, Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining

IHC (p)

Formalin-fixed and paraffin embedded: rat brain tissue labeled with Anti-FasL Polyclonal Antibody, Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining

IHC (p)

Jurkat lysates probed with Fas Ligand Polyclonal Antibody, Unconjugated at 1:1000 dilution and 4˚C overnight incubation.

Bone lysates probed with Fas Ligand Polyclonal Antibody, Unconjugated at 1:300 dilution and 4˚C overnight incubation.

(a) Effect of NAC on p,p'-DDE-induced FasL protein.

Effects of BDE47 on the production of intracellular ROS and the expression of apoptosis-related proteins in GC-1 cells.

Effect of BDE47 on daily sperm production and germ cell apoptosis in seminiferous tubules.

10 images

(9 references)

Catalog No. ABIN726410

Datasheet as PDF

Target See all FASL Antibodies

FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))
Binding Specificity
15

9

7

6

4

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 196-281
Reactivity
97

46

33

17

6

5

3

2

1
Human, Mouse, Rat, Pig
Host
68

28

10

5

4

1
Rabbit
Compatible Secondaries
Clonality
75

41
Polyclonal
Conjugate
66

12

10

6

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This FASL antibody is un-conjugated
Application
78

52

25

23

21

16

12

12

10

7

5

5

4

4

4

2

2

2

1

1

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity

Human, Mouse, Pig, Rat

Predicted Reactivity

Cow

Purification

Purified by Protein A.

Immunogen

KLH conjugated synthetic peptide derived from human Fas Ligand

Isotype

IgG
anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 100-200) antibody
FASL Reactivity: Human WB Host: Rabbit Polyclonal unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) antibody
FASL Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 102-280) antibody
FASL Reactivity: Rhesus Monkey WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 100-278) antibody
FASL Reactivity: Rat WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 103-281) antibody
FASL Reactivity: Human IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) antibody
FASL Reactivity: Human WB, FACS, IP, ICC Host: Mouse Monoclonal NOK-1 unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) antibody
FASL Reactivity: Human WB, FACS, IP, ICC, Func Host: Mouse Monoclonal NOK-1 unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 82-145) antibody
FASL Reactivity: Human WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 1-281) antibody
FASL Reactivity: Human WB, ELISA, IF, PLA Host: Mouse Monoclonal 2G9-G8 unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 196-220) antibody
FASL Reactivity: Mouse WB, FACS, ICC, IF Host: Rat Monoclonal H11 unconjugated

Application Notes

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions

For Research Use only
Format

Liquid

Concentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative

ProClin

Precaution of Use

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage

4 °C,-20 °C

Storage Comment

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date

12 months
Lv, Zheng, Zhou, Jia, Wang, Liu, Zhao, Ji, Li, Cao: "Antiproliferative and Apoptosis-inducing Effect of exo-Protoporphyrin IX based Sonodynamic Therapy on Human Oral Squamous Cell Carcinoma." in: Scientific reports, Vol. 7, pp. 40967, (2017) (PubMed).

Wang, Zhang, Yang, Luo, Zhang, Wang: "Lipopolysaccharide-induced expression of FAS ligand in cultured immature boar sertoli cells through the regulation of pro-inflammatory cytokines and miR-187." in: Molecular reproduction and development, (2015) (PubMed).

Song, Li, Shi, Lehmler, Fu, Su, Xia, Song, Song: "Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells." in: Chemical research in toxicology, Vol. 28, Issue 11, pp. 2160-9, (2015) (PubMed).

Peng, Fu, Guo, Zhang, Di, Jiang, Li: "Effects and Mechanism of Baicalin on Apoptosis of Cervical Cancer HeLa Cells I n -v itro." in: Iranian journal of pharmaceutical research : IJPR, Vol. 14, Issue 1, pp. 251-61, (2015) (PubMed).

Qi, Fu, Wang, Liu, Quan, Kourouma, Yan, Yu, Duan, Yang: "BPA-induced apoptosis of rat Sertoli cells through Fas/FasL and JNKs/p38 MAPK pathways." in: Reproductive toxicology (Elmsford, N.Y.), Vol. 50, pp. 108-16, (2014) (PubMed).

Chen, Xie, Xue, Ji, Chang, Ma, Bi: "Characterization of cytotoxicity-related gene expression in response to virulent Marek's disease virus infection in the bursa of Fabricius." in: Research in veterinary science, Vol. 94, Issue 3, pp. 496-503, (2013) (PubMed).

Shi, Song, Wang, Wang, Liang, Hu, Yu, Guan, Cheng, Yang: "β-Benzene hexachloride induces apoptosis of rat Sertoli cells through generation of reactive oxygen species and activation of JNKs and FasL." in: Environmental toxicology, Vol. 26, Issue 2, pp. 124-35, (2011) (PubMed).

Shi, Song, Wang, Liang, Hu, Guan, Cheng, Yang: "p,p'-DDE induces apoptosis of rat Sertoli cells via a FasL-dependent pathway." in: Journal of biomedicine & biotechnology, Vol. 2009, pp. 181282, (2009) (PubMed).
Target

FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Alternative Name

Fas Ligand (FASL Products)

Synonyms

ALPS1B antibody, APT1LG1 antibody, APTL antibody, CD178 antibody, CD95-L antibody, CD95L antibody, FASL antibody, TNFSF6 antibody, fasl antibody, Fas-L antibody, Faslg antibody, Tnfsf6 antibody, gld antibody, Apt1Lg1 antibody, Fasl antibody, FASLG antibody, zgc:162027 antibody, Fas ligand antibody, Fas ligand L homeolog antibody, Fas ligand (TNF superfamily, member 6) antibody, FASLG antibody, faslg.L antibody, Fasl antibody, Faslg antibody, faslg antibody

Background

Synonyms: APTL, FASL, CD178, CD95L, ALPS1B, CD95-L, TNFSF6, APT1LG1, Tumor necrosis factor ligand superfamily member 6, Apoptosis antigen ligand, CD95 ligand, Fas antigen ligand, Fas ligand, FASLG
Background: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.

Gene ID

356

UniProt

P48023

Pathways

Apoptosis, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity