HCLS1 antibody (N-Term)
(1 reference)-
- Target See all HCLS1 Antibodies
- HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HCLS1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- VNDISEKEQR WGAKTIEGSG RTEHINIHQL RNKVSEEHDV LRKKEMESGP
- Predicted Reactivity
- Cow: 86%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 86%
- Characteristics
- This is a rabbit polyclonal antibody against HCLS1. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human HCLS1
- Top Product
- Discover our top product HCLS1 Primary Antibody
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anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 266-355) antibody
HCLS1 Reactivity: Human WB, ELISA, IHC (p), PLA, RNAi Host: Mouse Monoclonal 1A8 unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 266-355) antibodyHCLS1 Reactivity: Human WB, ELISA, IHC (p), IF Host: Mouse Monoclonal 2A9 unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 161-260) antibodyHCLS1 Reactivity: Mouse WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) antibodyHCLS1 Reactivity: Human, Mouse WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 1-280) antibodyHCLS1 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 362-391), (C-Term) antibodyHCLS1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB34076 unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (C-Term) antibodyHCLS1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) antibodyHCLS1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 28-77) antibodyHCLS1 Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Guinea Pig, Pig WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (N-Term) antibodyHCLS1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 486 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells." in: The Biochemical journal, Vol. 364, Issue Pt 1, pp. 41-7, (2002) (PubMed).
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: "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells." in: The Biochemical journal, Vol. 364, Issue Pt 1, pp. 41-7, (2002) (PubMed).
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- Target
- HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))
- Alternative Name
- HCLS1 (HCLS1 Products)
- Synonyms
- CTTNL antibody, HS1 antibody, AW213261 antibody, HCLS1 antibody, hcls1 antibody, si:dkey-9a20.6 antibody, wu:fk96b08 antibody, zgc:154014 antibody, hematopoietic cell-specific Lyn substrate 1 antibody, hematopoietic cell specific Lyn substrate 1 antibody, hematopoietic lineage cell-specific protein-like antibody, HCLS1 antibody, Hcls1 antibody, LOC100223649 antibody, hcls1 antibody
- Background
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HCLS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets. This gene is a substrate for caspase cleavage during apoptosis.
Alias Symbols: HS1, CTTNL
Protein Interaction Partner: SH2D4A, UBC, Mbp, Dlg4, NOTCH1, QKI, TERF1, TRIM29, SSBP3, BLZF1, IKBKG, LZTR1, ZBTB25, HS1BP3, HAX1, ACTR2, MAP4K1, CASP3, SYK, WAS, LYN, FGR, CSNK2A1, CD79A, ACTA1, GRB2, ACTR3,
Protein Size: 486 - Molecular Weight
- 54 kDa
- Gene ID
- 3059
- NCBI Accession
- NM_005335, NP_005326
- UniProt
- P14317
- Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Myometrial Relaxation and Contraction, Maintenance of Protein Location
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