HDAC3 antibody (C-Term)
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- Target See all HDAC3 Antibodies
- HDAC3 (Histone Deacetylase 3 (HDAC3))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HDAC3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- HDAC3 Antibody detects endogenous levels of total HDAC3.
- Predicted Reactivity
- Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human HDAC3, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product HDAC3 Primary Antibody
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anti-Histone Deacetylase 3 (HDAC3) (AA 299-428) antibody
HDAC3 Reactivity: Human WB, IHC, IF, IP, ChIP Host: Rabbit Polyclonal unconjugated
anti-Histone Deacetylase 3 (HDAC3) (pSer424) antibodyHDAC3 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Histone Deacetylase 3 (HDAC3) antibodyHDAC3 Reactivity: Human, Mouse, Rat WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Histone Deacetylase 3 (HDAC3) (AA 1-428) antibodyHDAC3 Reactivity: Human WB, ELISA, IHC, IF, ChIP Host: Rabbit Polyclonal unconjugated
anti-Histone Deacetylase 3 (HDAC3) (AA 319-428) antibodyHDAC3 Reactivity: Human WB, ELISA, IF Host: Mouse Monoclonal 2A3 unconjugated
anti-Histone Deacetylase 3 (HDAC3) (C-Term) antibodyHDAC3 Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Histone Deacetylase 3 (HDAC3) antibodyHDAC3 Reactivity: Human, Mouse, Rat, Dog, Chicken WB, IHC (p), IF (p) Host: Rabbit Polyclonal unconjugated
anti-Histone Deacetylase 3 (HDAC3) (AA 1-428) antibodyHDAC3 Reactivity: Human ELISA, IF, IP Host: Mouse Monoclonal 2F9-4B7 unconjugated
anti-Histone Deacetylase 3 (HDAC3) (AA 31-130) antibodyHDAC3 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF (p), IF (cc), ICC, FACS, IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Histone Deacetylase 3 (HDAC3) antibodyHDAC3 Reactivity: Human WB, ELISA, IHC Host: Rabbit Monoclonal 4D4 unconjugated Recombinant Antibody
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- HDAC3 (Histone Deacetylase 3 (HDAC3))
- Alternative Name
- HDAC3 (HDAC3 Products)
- Synonyms
- CG2128 antibody, DHDAC3 antibody, DmHDAC3 antibody, Dmel\\CG2128 antibody, Dromel_CG2128_FBtr0078767_hdac3_mORF antibody, HDAC antibody, HDAC3 antibody, Hdac 3 antibody, dHDAC3 antibody, dmHDA402 antibody, hdac3 antibody, HDm antibody, hd3 antibody, RPD3 antibody, XRpd3 antibody, rpd3-2 antibody, HD3 antibody, RPD3-2 antibody, AW537363 antibody, zgc:55927 antibody, Histone deacetylase 3 antibody, histone deacetylase 3 antibody, histone deacetylase 3 S homeolog antibody, HDAC3 antibody, hdac3 antibody, CNL05260 antibody, Hdac3 antibody, hdac3.S antibody
- Background
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Description: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI3K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
Gene: HDAC3
- Molecular Weight
- 48kDa
- Gene ID
- 8841
- UniProt
- O15379
- Pathways
- Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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