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HGS antibody (Internal Region)

Name: HGS antibody (Internal Region)
SKU: ABIN6262232
Price: 390.77 USD
Availability: InStock

HGS Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

Western blot analysis of HGS expression in Rat brain lysate

Western blot analysis on HepG2 cell lysate using HGS Antibody.

IF/ICC

ABIN6266695 at 1/100 staining human pancreas tissue sections by IHC-P.

IHC

4 images

Catalog No. ABIN6262232

Datasheet as PDF

Target See all HGS Antibodies

HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
Binding Specificity
8

4

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Internal Region
Reactivity
45

31

21

3

2

1

1

1
Human, Mouse, Rat
Host
39

5

1
Rabbit
Compatible Secondaries
Clonality
42

3
Polyclonal
Conjugate
33

2

1

1

1

1

1

1

1

1

1

1
This HGS antibody is un-conjugated
Application
37

21

19

15

11

3

2

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity

HGS Antibody detects endogenous levels of total HGS.

Predicted Reactivity

Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken,Xenopus

Purification

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen

A synthesized peptide derived from human HGS, corresponding to a region within the internal amino acids.

Isotype

IgG

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anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 513-612) antibody
HGS Reactivity: Human WB, ELISA, IF, RNAi Host: Mouse Monoclonal 6D11 unconjugated

anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (C-Term) antibody
HGS Reactivity: Human WB, IF, IHC (p), ICC Host: Rabbit Polyclonal unconjugated

anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (Internal Region) antibody
HGS Reactivity: Human, Mouse, Rat WB, IF, IHC (p), EIA Host: Rabbit Polyclonal unconjugated

anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) antibody
HGS Reactivity: Human, Mouse, Rat WB, IHC, IF Host: Rabbit Polyclonal unconjugated

anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 513-612) antibody
HGS Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated

anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 301-350) antibody
HGS Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, IHC (p) Host: Rabbit Polyclonal unconjugated

anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (N-Term) antibody
HGS Reactivity: Human, Mouse WB, ELISA, IHC (p) Host: Rabbit Polyclonal unconjugated

anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 548-777) antibody
HGS Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated

anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 256-286), (N-Term) antibody
HGS Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB4400 unconjugated

anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) antibody
HGS Reactivity: Human WB, IF Host: Mouse Monoclonal 3H7 unconjugated

Application Notes

WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC: 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

-20 °C

Storage Comment

Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date

12 months
Target

HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))

Alternative Name

HGS (HGS Products)

Synonyms

HRS antibody, Hrs antibody, fi34f05 antibody, zgc:63492 antibody, wu:fi34f05 antibody, Hgr antibody, ZFYVE8 antibody, CG2903 antibody, Dmel\\CG2903 antibody, HRS-2 antibody, Vps27 antibody, hrs antibody, l(2)23AB5 antibody, l(2)23Ad antibody, l(2)23Ad(Hrs) antibody, vps27 antibody, hgs antibody, hepatocyte growth factor-regulated tyrosine kinase substrate antibody, HGF-regulated tyrosine kinase substrate antibody, Hepatocyte growth factor regulated tyrosine kinase substrate antibody, hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog antibody, HGS antibody, Hgs antibody, hgs antibody, Hrs antibody, hgs.L antibody

Background

Description: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
Gene: HGS

Molecular Weight

86kDa

Gene ID

9146

UniProt

O14964

Pathways

EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation