Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

LAT antibody

LAT Reactivity: Human, Mouse, Rat WB, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7074502
  • Target See all LAT Antibodies
    LAT (Linker For Activation of T Cells (LAT))
    Reactivity
    • 124
    • 57
    • 40
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 116
    • 8
    • 2
    • 1
    Rabbit
    Clonality
    • 118
    • 9
    Polyclonal
    Conjugate
    • 62
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This LAT antibody is un-conjugated
    Application
    • 72
    • 41
    • 39
    • 39
    • 18
    • 11
    • 11
    • 9
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Cross-Reactivity
    Human, Rat
    Purification
    Affinity purification
    Immunogen
    Recombinant protein corresponding to Mouse LAT
  • Application Notes
    WB (M,R) 1:500-1:1000, IHC/IF (H,M,R) 1:1000-1:4000/1:500-1:3000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS, pH 7.4, 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Target
    LAT (Linker For Activation of T Cells (LAT))
    Alternative Name
    LAT (LAT Products)
    Synonyms
    LAT antibody, lat antibody, LAT1 antibody, pp36 antibody, linker for activation of T-cells antibody, linker for activation of T cells antibody, LAT antibody, lat antibody, Lat antibody
    Background
    Linker for activation of T-cells family member 1 (LAT) is a single-pass type III membrane protein which is required for TCR (T-cell antigen receptor) and pre-TCR-mediated signaling, both in mature T-cells and during their development This protein is involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Functionally T cell receptor (TCR) activation results in tyrosine phosphorylation of LAT, leading to the direct interaction with several proteins, including PLC-gamma 1, Grb2 and Gads. These direct ligands then mediate the indirect interaction of LAT with proteins such as SLP-76, Vav1 and Itk. PLC-gamma 1, Vav1 and Itk contain pleckstrin homology (PH) domains that interact with the enzymatic product of phosphoinositide-3-kinase (PI3k).
    Molecular Weight
    38 kDa
    Gene ID
    16797
    NCBI Accession
    NP_034819
    UniProt
    O54957
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway
You are here: