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CD46 antibody (AA 251-355)

Name: CD46 antibody (AA 251-355)
SKU: ABIN687832
Price: 384.62 USD
Availability: InStock

CD46 Reactivity: Human, Mouse WB, FACS, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated

Formalin-fixed and paraffin embedded human breast carcinoma labeled with Rabbit Anti CD46/MCP Polyclonal Antibody, Unconjugated (ABIN687832) at 1:200 followed by conjugation to the secondary antibody and DAB staining

IHC

Human U937 cells probed with CD46/MCP Polyclonal Antibody, Unconjugated ( at 1:100 for 30 minutes followed by incubation with a PE Conjugated secondary (green) for 30 minutes compared to control cells (blue), secondary only (light blue) and isotype control (orange).

FACS

L1 mouse brain lysates L2 human colon carcinoma lysates probed with Anti CD46/MCP Polyclonal Antibody, Unconjugated (ABIN687832) at 1:200 in 4 °C.

SDS

Formalin-fixed and paraffin embedded rat brain labeled with Anti-CD46/MCP (human) Polyoclonal Antibody, Unconjugated (ABIN687832) at 1:200 followed by conjugation to the secondary antibody and DAB staining

IHC

4 images

Catalog No. ABIN687832

Datasheet as PDF

Target See all CD46 Antibodies

CD46
Binding Specificity
15

14

10

8

5

3

2

2

2

2

2

1

1

1

1

1

1

1
AA 251-355
Reactivity
116

38

20

10

10

1
Human, Mouse
Host
83

53

2
Rabbit
Compatible Secondaries
Clonality
72

66
Polyclonal
Conjugate
51

18

16

9

6

5

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
This CD46 antibody is un-conjugated
Application
90

79

43

39

32

19

13

13

13

9

6

5

5

2

2

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity

Human, Mouse

Purification

Purified by Protein A.

Immunogen

KLH conjugated synthetic peptide derived from Mouse CD46

Isotype

IgG

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anti-CD46 (CD46) (AA 40-320) antibody
CD46 Reactivity: Human WB, IF, IHC Host: Rabbit Polyclonal unconjugated

anti-CD46 (CD46) (AA 317-343) antibody
CD46 Reactivity: Human WB, FACS, ELISA, IF, IHC Host: Rabbit Polyclonal unconjugated

anti-CD46 (CD46) antibody
CD46 Reactivity: Human, Cow WB, FACS, IP Host: Mouse Monoclonal MEM-258 unconjugated

anti-CD46 (CD46) antibody
CD46 Reactivity: Human, Cow WB, FACS, IP Host: Mouse Monoclonal MEM-258 unconjugated

anti-CD46 (CD46) (AA 317-343), (C-Term) antibody
CD46 Reactivity: Human WB, FACS, IF, IHC (p) Host: Rabbit Polyclonal RB21743 unconjugated

anti-CD46 (CD46) antibody
CD46 Reactivity: Human WB, ELISA, IHC Host: Rabbit Monoclonal 7D12 unconjugated Recombinant Antibody

anti-CD46 (CD46) antibody (FITC)
CD46 Reactivity: Human, Cow FACS Host: Mouse Monoclonal MEM-258 FITC

anti-CD46 (CD46) antibody (Biotin)
CD46 Reactivity: Human, Cow WB, FACS, IP Host: Mouse Monoclonal MEM-258 Biotin

anti-CD46 (CD46) antibody (APC)
CD46 Reactivity: Human, Cow FACS Host: Mouse Monoclonal MEM-258 APC

Application Notes

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions

For Research Use only
Format

Liquid

Concentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative

ProClin

Precaution of Use

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage

4 °C,-20 °C

Storage Comment

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date

12 months
Target

CD46

Alternative Name

CD46/MCP (CD46 Products)

Background

Synonyms: MCP, TLX, AHUS2, MIC10, TRA2.10, Membrane cofactor protein, Trophoblast leukocyte common antigen, CD46
Background: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Gene ID

4179

UniProt

P15529

Pathways

Regulation of Actin Filament Polymerization