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DDR2 antibody (AA 245-350)

Name: DDR2 antibody (AA 245-350)
SKU: ABIN755218
Price: 384.62 USD
Availability: InStock

DDR2 Reactivity: Human, Mouse, Rat WB, ELISA, FACS, IF (cc) Host: Rabbit Polyclonal unconjugated

Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-CD167B/DDR2 Polyclonal Antibody, Unconjugated (ABIN755218) at 1:200 followed by conjugation to the secondary antibody and DAB staining

IHC

Mouse Heart lysates probed with CD167b'DDR2 Polyclonal Antibody, Unconjugated at 1:500 dilution and 4˚C overnight incubation.

2 images

(2 references)

Catalog No. ABIN755218

Datasheet as PDF

Target See all DDR2 Antibodies

DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))
Binding Specificity
9

9

8

7

6

4

2

1

1

1

1

1

1

1
AA 245-350
Reactivity
46

24

1

1
Human, Mouse, Rat
Host
52

7
Rabbit
Compatible Secondaries
Clonality
53

6
Polyclonal
Conjugate
28

6

6

5

4

4

1

1

1

1

1

1
This DDR2 antibody is un-conjugated
Application
45

38

21

6

3

3

2

2

1

1

1
Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity

Human, Mouse, Rat

Predicted Reactivity

Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification

Purified by Protein A.

Immunogen

KLH conjugated synthetic peptide derived from human CD167b/DDR2

Isotype

IgG

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DDR2 Reactivity: Human WB, ELISA, IHC, ICC Host: Mouse Monoclonal 3B11E4 unconjugated

anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) antibody
DDR2 Reactivity: Human WB, ELISA, IHC, FACS Host: Rabbit Polyclonal unconjugated

anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 578-817) antibody
DDR2 Reactivity: Human WB, ELISA, IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated

anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 447-540) antibody
DDR2 Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated

anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (C-Term) antibody
KO Validated DDR2 Reactivity: Human WB, IHC (p), ICC, IF Host: Rabbit Polyclonal unconjugated

anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 31-80) antibody
DDR2 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated

anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 816-843) antibody
DDR2 Reactivity: Mouse WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated

anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 290-320) antibody
DDR2 Reactivity: Human WB Host: Mouse Monoclonal 484CT5-5-4 unconjugated

anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 290-320) antibody
DDR2 Reactivity: Human WB Host: Rabbit Polyclonal RB01473 unconjugated

Application Notes

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IF(ICC) 1:50-200

Restrictions

For Research Use only
Format

Liquid

Concentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative

ProClin

Precaution of Use

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage

4 °C,-20 °C

Storage Comment

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date

12 months
Zhu, Gillespie, Jackson: "NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4." in: American journal of physiology. Heart and circulatory physiology, Vol. 309, Issue 9, pp. H1528-42, (2015) (PubMed).

Wang, Wang, Zhao, Li, Deng: "Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts." in: Biochemical pharmacology, Vol. 85, Issue 10, pp. 1486-94, (2013) (PubMed).
Target

DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Alternative Name

CD167b (DDR2 Products)

Background

Synonyms: TKT, MIG2a, NTRKR3, TYRO1, Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO1, CD167b, DDR2
Background: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

Gene ID

4921

UniProt

Q16832

Pathways

RTK Signaling