PTPN1 antibody
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- Target See all PTPN1 Antibodies
- PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PTPN1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Specificity
- This antibody ist KO validated.
- Characteristics
- Polyclonal Antibody
- Purification
- Affinity purification
- Grade
- KO Validated
- Immunogen
- Recombinant fusion protein of human PTPN1 (NP_002818.1).
- Isotype
- IgG
- Top Product
- Discover our top product PTPN1 Primary Antibody
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anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 40-246) antibody
PTPN1 Reactivity: Human WB, ELISA, IHC, FACS, ICC Host: Mouse Monoclonal 4F8F11 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) antibodyPTPN1 Reactivity: Human, Monkey, Dog WB, IHC, FACS, IF, IHC (p) Host: Mouse Monoclonal 1D10 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 1-100) antibodyPTPN1 Reactivity: Human, Mouse, Rat WB, ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (pSer50) antibodyPTPN1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) antibodyPTPN1 Reactivity: Human WB, ELISA, IHC Host: Rabbit Monoclonal 1G3 unconjugated Recombinant Antibody
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (N-Term) antibodyPTPN1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 40-246) antibodyPTPN1 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 4F8F2 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 268-406) antibodyPTPN1 Reactivity: Human WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 23-53), (N-Term) antibodyPTPN1 Reactivity: Human WB Host: Rabbit Polyclonal RB7011 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 221-249) antibodyPTPN1 Reactivity: Mouse WB Host: Rabbit Polyclonal RB41801 unconjugated
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- Application Notes
- WB 1:500-1:2000 IHC 1:50-1:200 IF 1:10-1:100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
- Alternative Name
- PTPN1 (PTPN1 Products)
- Synonyms
- PTPN1 antibody, PTP1B antibody, PTP-1B antibody, PTP-HA2 antibody, Ptp antibody, ptp1b antibody, wu:fk54h03 antibody, CPTP1 antibody, protein tyrosine phosphatase, non-receptor type 1 antibody, protein tyrosine phosphatase, non-receptor type 1 L homeolog antibody, PTPN1 antibody, Ptpn1 antibody, ptpn1 antibody, ptpn1.L antibody
- Background
- The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
- Molecular Weight
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Observed_MW: 50 kDa
Calculated_MW: 49 kDa
- Gene ID
- 5770
- UniProt
- P18031
- Pathways
- TLR Signaling, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling
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