ELANE antibody (AA 140-267)
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- Target See all ELANE Antibodies
- ELANE (Elastase, Neutrophil Expressed (ELANE))
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Binding Specificity
- AA 140-267
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Reactivity
- Human, Monkey
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This ELANE antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Neutralization (Neut)
- Purification
- purified
- Immunogen
- Purified recombinant fragment of human ELANE (AA: 140-267) expressed in E. coli.
- Clone
- 6B6B10
- Isotype
- IgG1
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anti-Elastase, Neutrophil Expressed (ELANE) (AA 30-267) antibody
ELANE Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-Elastase, Neutrophil Expressed (ELANE) (AA 30-247) antibodyELANE Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Elastase, Neutrophil Expressed (ELANE) (AA 140-267) antibodyELANE Reactivity: Human, Rat WB, ELISA, IHC, FACS, ICC, Neut Host: Mouse Monoclonal 6B6G6 unconjugated
anti-Elastase, Neutrophil Expressed (ELANE) (AA 101-200) antibodyELANE Reactivity: Human, Mouse, Rat WB, ELISA, FACS, IF (p), IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Elastase, Neutrophil Expressed (ELANE) (AA 30-267) antibodyELANE Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Elastase, Neutrophil Expressed (ELANE) antibodyELANE Reactivity: Human ELISA, IHC, FACS Host: Rabbit Monoclonal 2H12 unconjugated Recombinant Antibody
anti-Elastase, Neutrophil Expressed (ELANE) antibodyELANE Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Elastase, Neutrophil Expressed (ELANE) (AA 168-267) antibodyELANE Reactivity: Human WB, ELISA, IF Host: Mouse Monoclonal 4E11 unconjugated
anti-Elastase, Neutrophil Expressed (ELANE) antibodyELANE Reactivity: Human ELISA, IHC, IHC (p), IEP Host: Sheep Polyclonal unconjugated
anti-Elastase, Neutrophil Expressed (ELANE) (AA 27-265) antibodyELANE Reactivity: Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
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- Application Notes
- ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: 1:200 - 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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- Target
- ELANE (Elastase, Neutrophil Expressed (ELANE))
- Alternative Name
- ELANE (ELANE Products)
- Synonyms
- ELA2 antibody, GE antibody, HLE antibody, HNE antibody, NE antibody, PMN-E antibody, SCN1 antibody, Ela2 antibody, F430011M15Rik antibody, ela2 antibody, ELANE antibody, elastase, neutrophil expressed antibody, proteinase 3 antibody, ELANE antibody, Elane antibody, prtn3 antibody
- Background
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Description: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.
Aliases: GE, NE, HLE, HNE, ELA2, SCN1, PMN-E
- Molecular Weight
- 28.5 kDa
- Gene ID
- 1991
- HGNC
- 1991
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