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F4/80 antibody (AA 732-747)

EMR1 Reactivity: Mouse, Human, Rat FACS, WB, IHC (p), IF (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1387314
  • Target See all F4/80 (EMR1) Antibodies
    F4/80 (EMR1) (Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 1 (EMR1))
    Binding Specificity
    • 14
    • 7
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 732-747
    Reactivity
    • 91
    • 51
    • 29
    • 4
    • 4
    • 1
    Mouse, Human, Rat
    Host
    • 55
    • 46
    • 4
    • 3
    • 2
    • 1
    Rabbit
    Clonality
    • 55
    • 48
    • 2
    Polyclonal
    Conjugate
    • 42
    • 10
    • 9
    • 8
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This F4/80 antibody is un-conjugated
    Application
    • 79
    • 55
    • 24
    • 17
    • 13
    • 12
    • 12
    • 11
    • 11
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human EMR1
    Isotype
    IgG
  • Application Notes
    WB 1:100-1000
    FCM 1:20-100
    IHC-P 1:100-500
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Xue, Han, Ma, Wu, Qin, Liu, Hu, Hong, Hou: "Effect of Microenvironment on Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Hepatocytes In Vitro and In Vivo." in: BioMed research international, Vol. 2016, pp. 8916534, (2016) (PubMed).

    Tsang, Huang, Yang, Chi, Chiang, Wang, Andocs, Szasz, Li, Chi: "Improving immunological tumor microenvironment using electro-hyperthermia followed by dendritic cell immunotherapy." in: BMC cancer, Vol. 15, pp. 708, (2015) (PubMed).

    Kwan, Yeung, Liu, Wong, Shum, Lam, Cheng, Cheung, To: "Silver nanoparticles alter proteoglycan expression in the promotion of tendon repair." in: Nanomedicine : nanotechnology, biology, and medicine, Vol. 10, Issue 7, pp. 1375-83, (2014) (PubMed).

  • Target
    F4/80 (EMR1) (Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 1 (EMR1))
    Alternative Name
    Emr1 (EMR1 Products)
    Synonyms
    EMR1 antibody, TM7LN3 antibody, DD7A5-7 antibody, EGF-TM7 antibody, F4/80 antibody, Gpf480 antibody, Ly71 antibody, adhesion G protein-coupled receptor E1 antibody, ADGRE1 antibody, LOC100424335 antibody, Adgre1 antibody
    Background

    Synonyms: TM7LN3, EGF-like module-containing mucin-like hormone receptor-like 1, EGF-like module receptor 1, EMR1 hormone receptor, EMR1, Adhesion G Protein-Coupled Receptor E1, ADGRE1, Cell surface glycoprotein F4/80

    Background: The epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL (13). These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system (13). The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13 (1,3,4). The F4/80 Molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin (1). F4/80/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation (5,6). The function of F4/80/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages.

    Gene ID
    2015
    UniProt
    Q14246
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