CMYA5 antibody (C-Term)
CMYA5
Reactivity: Human, Mouse, Rat
ELISA, WB, IF, IHC (p)
Host: Rabbit
Polyclonal
unconjugated
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- Target See all CMYA5 products
- CMYA5 (Cardiomyopathy Associated 5 (CMYA5))
- Binding Specificity
- AA 3810-3860, C-Term
- Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CMYA5 antibody is un-conjugated
- Application
- ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- SPRYD2 antibody is predicted to not cross-react with other SPRYD protein family members. At least four isoforms of SPRYD2 are known to exist.
- Purification
- SPRYD2 Antibody is affinity chromatography purified via peptide column.
- Immunogen
- SPRYD2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SPRYD2. The immunogen is located within amino acids 3810 - 3860 of SPRYD2.
- Isotype
- IgG
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anti-Cardiomyopathy Associated 5 (CMYA5) (C-Term) antibody
CMYA5 Reactivity: Human, Mouse, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
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- Application Notes
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SPRYD2 antibody can be used for detection of SPRYD2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- SPRYD2 Antibody is supplied in PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,4 °C
- Storage Comment
- SPRYD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- CMYA5 (Cardiomyopathy Associated 5 (CMYA5))
- Alternative Name
- SPRYD2 (CMYA5 Products)
- Synonyms
- cmya5l antibody, DKFZp469P2126 antibody, C5orf10 antibody, SPRYD2 antibody, TRIM76 antibody, 2310076E16Rik antibody, 2310076E21Rik antibody, AA420382 antibody, AI504003 antibody, Srfsd antibody, Tims antibody, sr553 antibody, cardiomyopathy associated 5 antibody, CMYA5 antibody, cmya5 antibody, Cmya5 antibody
- Background
- SPRYD2 Antibody: SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.
- Gene ID
- 202333
- NCBI Accession
- NP_705838
- UniProt
- Q8N3K9
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