ZNF598 antibody (N-Term)
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- Target See all ZNF598 Antibodies
- ZNF598 (Zinc Finger Protein 598 (ZNF598))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ZNF598 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- ZFP598 Antibody detects endogenous levels of total ZFP598.
- Predicted Reactivity
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human ZFP598, corresponding to a region within N-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product ZNF598 Primary Antibody
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anti-Zinc Finger Protein 598 (ZNF598) (AA 28-126) antibody
ZNF598 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-Zinc Finger Protein 598 (ZNF598) (AA 28-126) antibodyZNF598 Reactivity: Human ELISA, IF Host: Mouse Monoclonal 1E2 unconjugated
anti-Zinc Finger Protein 598 (ZNF598) (AA 398-447) antibodyZNF598 Reactivity: Human, Rat, Horse WB Host: Rabbit Polyclonal unconjugated
anti-Zinc Finger Protein 598 (ZNF598) (AA 578-627) antibodyZNF598 Reactivity: Human, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
anti-Zinc Finger Protein 598 (ZNF598) (AA 120-420) antibodyZNF598 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- ZNF598 (Zinc Finger Protein 598 (ZNF598))
- Alternative Name
- ZNF598 (ZNF598 Products)
- Synonyms
- ZNF598 antibody, BC023040 antibody, Ntrap antibody, Znf598 antibody, Zfp598 antibody, wu:fc88f12 antibody, zinc finger protein 598 antibody, ZNF598 antibody, znf598 antibody, Zfp598 antibody
- Background
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Description: E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843). Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931).
Gene: ZNF598
- Molecular Weight
- 98 kDa
- Gene ID
- 90850
- UniProt
- Q86UK7
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