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TYROBP antibody

TYROBP Reactivity: Mouse, Rat IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7261337
  • Target See all TYROBP Antibodies
    TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))
    Reactivity
    • 49
    • 19
    • 3
    Mouse, Rat
    Host
    • 65
    • 1
    • 1
    Rabbit
    Clonality
    • 58
    • 9
    Polyclonal
    Conjugate
    • 21
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This TYROBP antibody is un-conjugated
    Application
    • 41
    • 30
    • 26
    • 26
    • 21
    • 17
    • 12
    • 6
    • 4
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human TYROBP (NP_003323.1).
    Isotype
    IgG
    Top Product
    Discover our top product TYROBP Primary Antibody
  • Application Notes
    IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))
    Alternative Name
    TYROBP (TYROBP Products)
    Synonyms
    TYROBP antibody, DAP12 antibody, tyrpbp antibody, Karap antibody, KARAP antibody, PLOSL antibody, Ly83 antibody, dap12 antibody, TYRO protein tyrosine kinase binding protein antibody, Tyro protein tyrosine kinase binding protein antibody, TYROBP antibody, tyrobp antibody, Tyrobp antibody
    Background
    This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70 kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.
    Gene ID
    7305
    UniProt
    O43914
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