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FBXO11 antibody (AA 65-160)

FBXO11 Reactivity: Human ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1386847
  • Target See all FBXO11 Antibodies
    FBXO11 (F-Box Protein 11 (FBXO11))
    Binding Specificity
    • 14
    • 7
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 65-160
    Reactivity
    • 62
    • 18
    • 15
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 56
    • 5
    • 1
    Rabbit
    Clonality
    • 59
    • 3
    Polyclonal
    Conjugate
    • 27
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This FBXO11 antibody is un-conjugated
    Application
    • 34
    • 24
    • 12
    • 12
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Predicted Reactivity
    Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FBXO11
    Isotype
    IgG
    Top Product
    Discover our top product FBXO11 Primary Antibody
  • Application Notes
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    FBXO11 (F-Box Protein 11 (FBXO11))
    Alternative Name
    FBXO11 (FBXO11 Products)
    Synonyms
    FBX11 antibody, PRMT9 antibody, UBR6 antibody, VIT1 antibody, C80048 antibody, Jf antibody, Vit1 antibody, fbxo11 antibody, MGC84634 antibody, FBXO11 antibody, im:6906507 antibody, wu:fj83f06 antibody, zgc:153171 antibody, Fbxo11 antibody, DKFZp459P2410 antibody, F-box protein 11 antibody, F-box protein 11 L homeolog antibody, F-box protein 11a antibody, F-box only protein 11 antibody, hypothetical protein antibody, FBXO11 antibody, Fbxo11 antibody, fbxo11.L antibody, fbxo11a antibody, CpipJ_CPIJ009919 antibody, CpipJ_CPIJ017549 antibody, Bm1_52225 antibody, LOAG_16571 antibody, fbxo11 antibody, LOC100115478 antibody
    Background

    Synonyms: UBR6, VIT1, FBX11, PRMT9, UG063H01, F-box only protein 11, Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1, FBXO11

    Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.

    Gene ID
    80204
    UniProt
    Q86XK2
    Pathways
    Sensory Perception of Sound
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