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WAC antibody (AA 210-260)

WAC Reactivity: Human, Mouse, Rat ELISA, WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6991845
  • Target See all WAC Antibodies
    WAC (WW Domain Containing Adaptor with Coiled-Coil (WAC))
    Binding Specificity
    • 7
    • 7
    • 6
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 210-260
    Reactivity
    Human, Mouse, Rat
    Host
    • 22
    Rabbit
    Clonality
    • 22
    Polyclonal
    Conjugate
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    This WAC antibody is un-conjugated
    Application
    • 17
    • 17
    • 13
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    At least two isoforms of WAC are known to exist, this antibody will detect the larger isoform.
    Purification
    WAC Antibody is affinity chromatography purified via peptide column.
    Immunogen
    WAC antibody was raised against a 19 amino acid peptide near the center of human WAC . The immunogen is located within amino acids 210 - 260 of WAC.
    Isotype
    IgG
    Top Product
    Discover our top product WAC Primary Antibody
  • Application Notes
    WAC Antibody can be used for detection of WAC by Western blot at 1 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    WAC Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    WAC antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target
    WAC (WW Domain Containing Adaptor with Coiled-Coil (WAC))
    Alternative Name
    WAC (WAC Products)
    Synonyms
    BM-016 antibody, PRO1741 antibody, Wwp4 antibody, 1110067P07Rik antibody, A230035H12Rik antibody, AI256735 antibody, AI256776 antibody, DKFZp468H162 antibody, wac antibody, wu:fc13f04 antibody, wu:fj68f01 antibody, zgc:55755 antibody, RGD1562407 antibody, zgc:101828 antibody, WW domain containing adaptor with coiled-coil antibody, WW domain containing adaptor with coiled-coil a antibody, WW domain containing adaptor with coiled-coil b antibody, WAC antibody, Wac antibody, wac antibody, waca antibody, wacb antibody
    Background
    WAC Antibody: The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.
    Molecular Weight
    Predicted: 71 kDa

    Observed: 75 kDa
    Gene ID
    51322
    NCBI Accession
    NP_057712
    UniProt
    Q9BTA9
    Pathways
    Chromatin Binding
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