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FGFR3 antibody (AA 529-694)

FGFR3 Reactivity: Human WB, ELISA, IHC, ICC, FACS Host: Mouse Monoclonal 2H10B4 unconjugated
Catalog No. ABIN5542298
  • Target See all FGFR3 Antibodies
    FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))
    Binding Specificity
    • 17
    • 15
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 529-694
    Reactivity
    • 116
    • 50
    • 42
    • 4
    • 1
    • 1
    • 1
    Human
    Host
    • 110
    • 6
    • 1
    Mouse
    Clonality
    • 98
    • 19
    Monoclonal
    Conjugate
    • 40
    • 13
    • 9
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    This FGFR3 antibody is un-conjugated
    Application
    • 87
    • 47
    • 45
    • 13
    • 13
    • 10
    • 10
    • 9
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human FGFR3 (AA: 529-694) expressed in E. coli.
    Clone
    2H10B4
    Isotype
    IgG1
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: , FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Target
    FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))
    Alternative Name
    FGFR3 (FGFR3 Products)
    Synonyms
    FGFR3 antibody, LOC100034114 antibody, ACH antibody, CD333 antibody, CEK2 antibody, HSFGFR3EX antibody, JTK4 antibody, FR3 antibody, Fgfr-3 antibody, Flg-2 antibody, HBGFR antibody, Mfr3 antibody, sam3 antibody, fc27h01 antibody, wu:fc27h01 antibody, fibroblast growth factor receptor 3 antibody, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog antibody, FGFR3 antibody, fgfr3.S antibody, Fgfr3 antibody, fgfr3 antibody
    Background

    Description: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009],

    Aliases: ACH, CEK2, JTK4, CD333, HSFGFR3EX

    Molecular Weight
    87.7 kDa
    Gene ID
    2261
    HGNC
    2261
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding
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