YES1 antibody (pTyr426)
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- Target See all YES1 Antibodies
- YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))
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Binding Specificity
- pTyr426
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This YES1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- Due to the highly conserved nature of this protein, this antibody will react with the related proteins LCK(Tyr394), Src(Tyr418), and Lyn (Tyr397) if phosphorylated at this site due to homology.
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic phosphopeptide derived from human YES1 around the phosphorylation site of Tyr426
- Isotype
- IgG
- Top Product
- Discover our top product YES1 Primary Antibody
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anti-V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) (AA 1-155) antibody
YES1 Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) (AA 1-80) antibodyYES1 Reactivity: Human WB, ELISA, PLA Host: Mouse Monoclonal 3C6 unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) (AA 1-543) antibodyYES1 Reactivity: Human WB, ELISA, IHC (p) Host: Mouse Monoclonal 2D5 unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) (AA 441-541) antibodyYES1 Reactivity: Human, Mouse WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) (AA 284-541) antibodyYES1 Reactivity: Human, Mouse WB, IHC, IHC (p), IF, ICC Host: Rabbit Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) (Center) antibodyYES1 Reactivity: Human, Mouse WB, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) (AA 1-543) antibodyYES1 Reactivity: Human WB, ELISA, RNAi Host: Mouse Monoclonal 2F4 unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) antibodyYES1 Reactivity: Human, Dog, Zebrafish (Danio rerio) WB, IHC (p), IF Host: Rabbit Polyclonal unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) (AA 1-30), (N-Term) antibodyYES1 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB3091 unconjugated
anti-V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) (AA 10-193) antibodyYES1 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 2F3E6 unconjugated
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- Application Notes
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WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- YES1 (V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1))
- Alternative Name
- Yes1 (YES1 Products)
- Background
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Synonyms: Yes, c-yes, HsT441, P61-YES, Tyrosine-protein kinase Yes, Proto-oncogene c-Yes, YES1
Background: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
- Gene ID
- 7525
- UniProt
- P07947
- Pathways
- CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling
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